C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay
Correspondence: Graciela Russomando, grusso@rieder.net.py; Jonathan Hoffmann, jonathan.hoffmann@fondation-merieux.org
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| Format: | article |
| Language: | English |
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2024
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| Online Access: | https://doi.org/10.3389/fimmu.2024.1308015 http://hdl.handle.net/20.500.14066/4587 |
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| _version_ | 1870612064051920896 |
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| author | Russomando Alvarez, Graciela Mabel |
| author2 | Sanabria Martínez, Diana Leticia Díaz Acosta, Chyntia Carolina Arenas, Rossana Rojas Vera, Leticia Elizabeth Franco, Laura Ximena Arenas Chaparro, María Rossana Delogu, Giovanni Bousso Ndiaye, Mame Diarra Bayaa, Rim Rakotosamimanana, Niaina Goletti, Delia Hoffmann, Jonathan |
| author2_role | author author author author author author author author author author author author |
| author_browse | Arenas Chaparro, María Rossana Arenas, Rossana Bayaa, Rim Bousso Ndiaye, Mame Diarra Delogu, Giovanni Díaz Acosta, Chyntia Carolina Franco, Laura Ximena Goletti, Delia Hoffmann, Jonathan Rakotosamimanana, Niaina Rojas Vera, Leticia Elizabeth Russomando Alvarez, Graciela Mabel Sanabria Martínez, Diana Leticia |
| author_facet | Russomando Alvarez, Graciela Mabel Sanabria Martínez, Diana Leticia Díaz Acosta, Chyntia Carolina Arenas, Rossana Rojas Vera, Leticia Elizabeth Franco, Laura Ximena Arenas Chaparro, María Rossana Delogu, Giovanni Bousso Ndiaye, Mame Diarra Bayaa, Rim Rakotosamimanana, Niaina Goletti, Delia Hoffmann, Jonathan |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4587/1/C1q%20and%20HBHA-specific%20IL-13%20levels%20as%20surrogate%20plasma%20biomarkers%20for%20monitoring%20tuberculosis%20treatment%20efficacy.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4587/5/Material%20suplementario.zip http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4587/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4587/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4587/4/C1q%20and%20HBHA-specific%20IL-13%20levels%20as%20surrogate%20plasma%20biomarkers%20for%20monitoring%20tuberculosis%20treatment%20efficacy.pdf.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4587/6/C1q%20and%20HBHA-specific%20IL-13%20levels%20as%20surrogate%20plasma%20biomarkers%20for%20monitoring%20tuberculosis%20treatment%20efficacy.jpg |
| dc.contributor.other.es.fl_str_mv | Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud |
| dc.creator.none.fl_str_mv | Russomando Alvarez, Graciela Mabel Sanabria Martínez, Diana Leticia Díaz Acosta, Chyntia Carolina Arenas, Rossana Rojas Vera, Leticia Elizabeth Franco, Laura Ximena Arenas Chaparro, María Rossana Delogu, Giovanni Bousso Ndiaye, Mame Diarra Bayaa, Rim Rakotosamimanana, Niaina Goletti, Delia Hoffmann, Jonathan |
| dc.date.accessioned.none.fl_str_mv | 2025-06-10T21:28:45Z |
| dc.date.available.none.fl_str_mv | 2025-06-10T21:28:45Z |
| dc.date.issued.none.fl_str_mv | 2024-03-13 |
| dc.format.extent.es.fl_str_mv | 10 páginas |
| dc.identifier.citation.en.fl_str_mv | Russomando, G., Sanabria, D., Díaz Acosta, C. C., Rojas, L., Franco L., Arenas, R., Delogu, G., Bousso Ndiaye M. D., Bayaa, R., Rakotosamimanana, N., Goletti, D., & Hoffmann, J. (2024). C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay. Frontiers in Immunology, 15, Article 1308015. https://doi.org/10.3389/fimmu.2024.1308015 |
| dc.identifier.doi.es.fl_str_mv | 10.3389/fimmu.2024.1308015 |
| dc.identifier.essn.es.fl_str_mv | 1664-3224 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.3389/fimmu.2024.1308015 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4587 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.en.fl_str_mv | International Union of Immunological Societies |
| dc.publisher.es.fl_str_mv | Frontiers Media S.A. |
| dc.relation.projectCONACYT.es.fl_str_mv | PINV18-1322 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.es.fl_str_mv | 7. Salud 7.3. Prevención, vigilancia y control de enfermedades transmisibles y no transmisibles |
| dc.subject.ocde.es.fl_str_mv | 3. Ciencias Médicas y de la Salud 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| dc.subject.other.es.fl_str_mv | Host biomarkers Immunodiagnostic Plasma protein signature Pulmonary tuberculosis Treatment immunomonitoring |
| dc.title.es.fl_str_mv | C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Correspondence: Graciela Russomando, grusso@rieder.net.py; Jonathan Hoffmann, jonathan.hoffmann@fondation-merieux.org |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_02ca2addf2cacdd8c4ceef2987cc2971 |
| identifier_str_mv | Russomando, G., Sanabria, D., Díaz Acosta, C. C., Rojas, L., Franco L., Arenas, R., Delogu, G., Bousso Ndiaye M. D., Bayaa, R., Rakotosamimanana, N., Goletti, D., & Hoffmann, J. (2024). C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay. Frontiers in Immunology, 15, Article 1308015. https://doi.org/10.3389/fimmu.2024.1308015 10.3389/fimmu.2024.1308015 1664-3224 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4587 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | 10236001043600348600f0c36c71-f913-4d86-ac84-b3f3b9e8eb4a60013594780-4998-444e-b28e-382f94b334436004526001891c568-1671-4cdf-8f41-ca410b5f055f600ce26e7fa-5b3b-487c-bed9-3994f712a5c4600b5d13d0d-d254-4d21-bfcb-703d071623d16006d49eb68-0bf6-45e0-abbc-f9642c4ad0826000739782d-30f2-4a48-99f4-f929e1d7d3fd6008cc05825-580c-4c61-9d55-9b5a2f3b367c6000ccae167-14ab-4316-af77-6295ed2b3ee4600Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud2025-06-10T21:28:45Z2025-06-10T21:28:45Z2024-03-13Russomando, G., Sanabria, D., Díaz Acosta, C. C., Rojas, L., Franco L., Arenas, R., Delogu, G., Bousso Ndiaye M. D., Bayaa, R., Rakotosamimanana, N., Goletti, D., & Hoffmann, J. (2024). C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay. Frontiers in Immunology, 15, Article 1308015. https://doi.org/10.3389/fimmu.2024.1308015https://doi.org/10.3389/fimmu.2024.1308015http://hdl.handle.net/20.500.14066/458710.3389/fimmu.2024.13080151664-3224Correspondence: Graciela Russomando, grusso@rieder.net.py; Jonathan Hoffmann, jonathan.hoffmann@fondation-merieux.orgIntroduction: New diagnostic tools are needed to rapidly assess the efficacy of pulmonary tuberculosis (PTB) treatment. The aim of this study was to evaluate several immune biomarkers in an observational and cross-sectional cohort study conducted in Paraguay. Methods: Thirty-two patients with clinically and microbiologically confirmed PTB were evaluated before starting treatment (T0), after 2 months of treatment (T1) and at the end of treatment (T2). At each timepoint plasma levels of IFN-y, 17 pro- and anti-inflammatory cytokines/chemokines and complement factors C1q, C3 and C4 were assessed in unstimulated and Mtb-specific stimulated whole blood samples using QuantiFERON-TB gold plus and recombinant Mycobacterium smegmatis heparin binding hemagglutinin (rmsHBHA) as stimulation antigen. Complete blood counts and liver enzyme assays were also evaluated and correlated with biomarker levels in plasma. Results: In unstimulated plasma, C1q (P<0.001), C4 (P<0.001), hemoglobin (P<0.001), lymphocyte proportion (P<0.001) and absolute white blood cell count (P=0.01) were significantly higher in PTB patients at baseline than in cured patients. C1q and C4 levels were found to be related to Mycobacterium tuberculosis load in sputum. Finally, a combinatorial analysis identified a plasma host signature comprising the detection of C1q and IL-13 levels in response to rmsHBHA as a tool differentiating PTB patients from cured TB profiles, with an AUC of 0.92 (sensitivity 94% and specificity 79%). Conclusion: This observational study provides new insights on host immune responses throughout anti-TB treatment and emphasizes the role of host C1q and HBHA-specific IL-13 response as surrogate plasma biomarkers for monitoring TB treatment efficacy.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrollo10 páginasengFrontiers Media S.A.International Union of Immunological SocietiesAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2024 Russomando, Sanabria, Díaz Acosta, Rojas, Franco, Arenas, Delogu, Ndiaye, Bayaa, Rakotosamimanana, Goletti and Hoffmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.7. Salud7.3. Prevención, vigilancia y control de enfermedades transmisibles y no transmisiblesHost biomarkersImmunodiagnosticPlasma protein signaturePulmonary tuberculosisTreatment immunomonitoring3. Ciencias Médicas y de la Salud3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología)C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguayinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionFrontiers in ImmunologyPINV18-132215Russomando Alvarez, Graciela MabelSanabria Martínez, Diana LeticiaDíaz Acosta, Chyntia CarolinaArenas, RossanaRojas Vera, Leticia ElizabethFranco, Laura XimenaArenas Chaparro, María RossanaDelogu, GiovanniBousso Ndiaye, Mame DiarraBayaa, RimRakotosamimanana, NiainaGoletti, DeliaHoffmann, JonathanORIGINALC1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy.pdfC1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy.pdfArtículo científicoapplication/pdf1879869http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4587/1/C1q%20and%20HBHA-specific%20IL-13%20levels%20as%20surrogate%20plasma%20biomarkers%20for%20monitoring%20tuberculosis%20treatment%20efficacy.pdf5fa4fd9ae8d64ec8c11dca2c78a50870MD51Material suplementario.zipMaterial suplementario.zipMaterial suplementarioapplication/octet-stream145629http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4587/5/Material%20suplementario.zip733ff759cb84997119b89b3501ee5132MD55CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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| spellingShingle | C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay Russomando Alvarez, Graciela Mabel 7. Salud 7.3. Prevención, vigilancia y control de enfermedades transmisibles y no transmisibles Host biomarkers Immunodiagnostic Plasma protein signature Pulmonary tuberculosis Treatment immunomonitoring 3. Ciencias Médicas y de la Salud 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| status_str | publishedVersion |
| title | C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay |
| title_full | C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay |
| title_fullStr | C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay |
| title_full_unstemmed | C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay |
| title_short | C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay |
| title_sort | C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay |
| topic | 7. Salud 7.3. Prevención, vigilancia y control de enfermedades transmisibles y no transmisibles Host biomarkers Immunodiagnostic Plasma protein signature Pulmonary tuberculosis Treatment immunomonitoring 3. Ciencias Médicas y de la Salud 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| url | https://doi.org/10.3389/fimmu.2024.1308015 http://hdl.handle.net/20.500.14066/4587 |