The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis
Corresponding author: Enrique Pandolfi, Professor PhD Principal Investigator of the Organic Chemistry Department Avenida General Flores 2124, CP 11800, Montevideo, Uruguay. Tel.: +598-2924-7881 Fax: +598-2924-1906 Email: epandolf@fq.edu.uy Antonieta Rojas de Arias, PhD Technical Director of the Cent...
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| 其他作者: | , , , , |
| 格式: | article |
| 語言: | 英语 |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://doi.org/10.3855/jidc.10622 http://hdl.handle.net/20.500.14066/4431 |
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| _version_ | 1870885383519076352 |
|---|---|
| author | Rolón, Miriam Soledad |
| author2 | Peixoto de Abreu Lima, Alejandro Coronel, Cathia Cecilia Vega Gómez, María Celeste Pandolfi, Enrique Rojas de Arias, Gladys Antonieta |
| author2_role | author author author author author |
| author_browse | Coronel, Cathia Cecilia Pandolfi, Enrique Peixoto de Abreu Lima, Alejandro Rojas de Arias, Gladys Antonieta Rolón, Miriam Soledad Vega Gómez, María Celeste |
| author_facet | Rolón, Miriam Soledad Peixoto de Abreu Lima, Alejandro Coronel, Cathia Cecilia Vega Gómez, María Celeste Pandolfi, Enrique Rojas de Arias, Gladys Antonieta |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/1/The%20efficacy%20of%20new%202%2c5-dihydroxybenzyl%20derivatives%20against%20Trypanosoma.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/4/The%20efficacy%20of%20new%202%2c5-dihydroxybenzyl%20derivatives%20against%20Trypanosoma.jpg http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/5/The%20efficacy%20of%20new%202%2c5-dihydroxybenzyl%20derivatives%20against%20Trypanosoma.pdf.txt |
| dc.creator.none.fl_str_mv | Rolón, Miriam Soledad Peixoto de Abreu Lima, Alejandro Coronel, Cathia Cecilia Vega Gómez, María Celeste Pandolfi, Enrique Rojas de Arias, Gladys Antonieta |
| dc.date.accessioned.none.fl_str_mv | 2024-07-16T18:27:58Z |
| dc.date.available.none.fl_str_mv | 2024-07-16T18:27:58Z |
| dc.date.issued.none.fl_str_mv | 2019-06-30 |
| dc.identifier.citation.en.fl_str_mv | Rolón, M., Peixoto de Abreu Lima, A., Coronel, C., Vega, M. C., Pandolfi, E., & Rojas de Arias, A. (2019). The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis. The Journal of Infection in Developing Countries, 13(06), 565-576. https://doi.org/10.3855/jidc.10622 |
| dc.identifier.doi.es.fl_str_mv | 10.3855/jidc.10622 |
| dc.identifier.issn.es.fl_str_mv | 1972-2680 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.3855/jidc.10622 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4431 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | The Journal of Infection in Developing Countries |
| dc.relation.projectCONACYT.es.fl_str_mv | BID 1698/OC-PR 09-INV-06 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.es.fl_str_mv | 7. Salud |
| dc.subject.other.es.fl_str_mv | Antiprotozoal activity Leishmania braziliensis Leishmania infantum Phenolic derivatives Trypanosome cruzi |
| dc.title.es.fl_str_mv | The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Corresponding author: Enrique Pandolfi, Professor PhD Principal Investigator of the Organic Chemistry Department Avenida General Flores 2124, CP 11800, Montevideo, Uruguay. Tel.: +598-2924-7881 Fax: +598-2924-1906 Email: epandolf@fq.edu.uy Antonieta Rojas de Arias, PhD Technical Director of the Center for Development and Scientific Research (CEDIC) Manduvirá 635, CP 1255, Asunción, Paraguay. Tel.: +595-981-504996 Fax: +595-21-441513 Email: rojasdearias@gmail.com |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_2f36c55d2981c224e35da369316bccb9 |
| identifier_str_mv | Rolón, M., Peixoto de Abreu Lima, A., Coronel, C., Vega, M. C., Pandolfi, E., & Rojas de Arias, A. (2019). The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis. The Journal of Infection in Developing Countries, 13(06), 565-576. https://doi.org/10.3855/jidc.10622 1972-2680 10.3855/jidc.10622 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4431 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | 1006600e221ef04-2f99-4c93-8fb8-7ac068dd736960030860011456000000-0001-6291-431603bfbcb2-b0a8-43be-9cdc-bcb988a9fa0e6009976000000-0002-6207-18702024-07-16T18:27:58Z2024-07-16T18:27:58Z2019-06-30Rolón, M., Peixoto de Abreu Lima, A., Coronel, C., Vega, M. C., Pandolfi, E., & Rojas de Arias, A. (2019). The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis. The Journal of Infection in Developing Countries, 13(06), 565-576. https://doi.org/10.3855/jidc.106221972-2680https://doi.org/10.3855/jidc.10622http://hdl.handle.net/20.500.14066/443110.3855/jidc.10622Corresponding author: Enrique Pandolfi, Professor PhD Principal Investigator of the Organic Chemistry Department Avenida General Flores 2124, CP 11800, Montevideo, Uruguay. Tel.: +598-2924-7881 Fax: +598-2924-1906 Email: epandolf@fq.edu.uy Antonieta Rojas de Arias, PhD Technical Director of the Center for Development and Scientific Research (CEDIC) Manduvirá 635, CP 1255, Asunción, Paraguay. Tel.: +595-981-504996 Fax: +595-21-441513 Email: rojasdearias@gmail.comIntroduction: Chagas disease and Leishmaniasis are among the most important parasitic diseases. They are considered to be within the most relevant group of neglected tropical diseases and have been included as priorities for searching new drugs due to their several treatment limitations. These parasitic diseases caused by flagellated protozoans affect more than 20 million people predominantly in developing countries. Methodology: In this study, we prepared a series of 2-substituted 1,4-benzenediols by an efficient, green, and lithium salt-free synthesis in water/ethanol as solvent to test their anti-parasitic activity. All 36 phenolic derivatives were evaluated in vitro for their activity against T. cruzi epimastigotes, L. infantum, and L. braziliensis promastigotes, as well as their cytotoxicity on macrophage and fibroblast cell lines. Results: Based on the results obtained, the compounds that presented a methyl, trifluoromethyl or bromo group at the para-position of the second benzene ring were found the most active analogs, with higher selective index values on the three parasites assayed. Conclusion: This evidence suggests that the anti-parasitic activity observed in these analogs is affected by the size of the group at the 4-position of the second ring, but not related with electronic factors. This study identified hit compounds with the potential to target several kinetoplastid parasites.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Programa Nacional de Incentivo a los InvestigadoresPrograma de Apoyo al Desarrollo de la Ciencia, Tecnología e InnovaciónengThe Journal of Infection in Developing CountriesAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2019 Rolón et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.7. SaludAntiprotozoal activityLeishmania braziliensisLeishmania infantumPhenolic derivativesTrypanosome cruziThe efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6The Journal of Infection in Developing Countries565576BID 1698/OC-PR 09-INV-0613Rolón, Miriam SoledadPeixoto de Abreu Lima, AlejandroCoronel, Cathia CeciliaVega Gómez, María CelestePandolfi, EnriqueRojas de Arias, Gladys AntonietaORIGINALThe efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma.pdfThe efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma.pdfArtículo científicoapplication/pdf852163http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/1/The%20efficacy%20of%20new%202%2c5-dihydroxybenzyl%20derivatives%20against%20Trypanosoma.pdfc3275a3c26725b4ecc1e9483dd174a93MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/2/license_rdf0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/3/license.txt858b22fda432bd774e469302988c1974MD53THUMBNAILThe efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma.jpgThe efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma.jpgPortadaimage/jpeg1128092http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/4/The%20efficacy%20of%20new%202%2c5-dihydroxybenzyl%20derivatives%20against%20Trypanosoma.jpg92f6cd6daf144cb668a6f6763bea43b9MD54TEXTThe efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma.pdf.txtThe efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma.pdf.txtExtracted texttext/plain52908http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4431/5/The%20efficacy%20of%20new%202%2c5-dihydroxybenzyl%20derivatives%20against%20Trypanosoma.pdf.txtb7b11957a25ae27ba051756ded9298caMD5520.500.14066/4431oai:repositorio.conacyt.gov.py:20.500.14066/44312026-02-12 19:30:36.958Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.pyQWwgYWNlcHRhciBlc3RhIGxpY2VuY2lhLCB1c3RlZCBjb21vIGF1dG9yIHkgcHJvcGlldGFyaW8gZGUgbG9zIGRlcmVjaG9zIGRlIHByb3BpZWRhZCBpbnRlbGVjdHVhbCBkZSBzdSBvYnJhIG90b3JnYSBhbCBSZXBvc2l0b3JpbyBJbnN0aXR1Y2lvbmFsIENPTkFDWVQgZWwgZGVyZWNobyBubyBleGNsdXNpdm8gZGUgcmVwcm9kdWNjacOzbiB5IGRpc3RyaWJ1Y2nDs24gZGUgc3Ugb2JyYSBlbiBjdWFscXVpZXIgZm9ybWF0byB5IG1lZGlvLgoKQWNlcHRhIHF1ZSwgc2luIG1vZGlmaWNhciBlbCBjb250ZW5pZG8sIHNlIHB1ZWRhIGNvbnZlcnRpciBzdSBvYnJhIGEgb3RybyBmb3JtYXRvIGNvbiBmaW5lcyBkZSBwcmVzZXJ2YWNpw7NuLiBBc8OtIG1pc21vLCBhY2VwdGEgcXVlIHNlIHB1ZWRhIGNvbnNlcnZhciBtw6FzIGRlIHVuYSBjb3BpYSBwb3IgbW90aXZvcyBkZSBzZWd1cmlkYWQgeSBwcmVzZXJ2YWNpw7NuLgoKVXN0ZWQgZGVjbGFyYSBxdWUgZWwgdHJhYmFqbyBwcmVzZW50YWRvIGVzIG9yaWdpbmFsIHkgcXVlIGN1ZW50YSBjb24gbGEgcG90ZXN0YWQgcGFyYSBvdG9yZ2FyIGxvcyBkZXJlY2hvcyBkZXRhbGxhZG9zIGVuIGVzdGEgbGljZW5jaWEuIFRhbWJpw6luIGRlY2xhcmEgcXVlIHN1IG9icmEgbm8gaW5mcmluZ2UgbG8gZXN0YWJsZWNpZG8gZW4gbGEgdmlnZW50ZSBsZWdpc2xhY2nDs24gc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsLgoKU2kgbGEgb2JyYSBjb250aWVuZSBtYXRlcmlhbCBwYXJhIGVsIGN1YWwgbm8gdGllbmUgZGVyZWNob3MgZGUgYXV0b3IsIHVzdGVkIGRlY2xhcmEgcXVlIGhhIG9idGVuaWRvIGxvcyBwZXJtaXNvcyBuZWNlc2FyaW9zIGRlbCBwcm9waWV0YXJpbyBwYXJhIG90b3JnYXIgYWwgUmVwb3NpdG9yaW8gSW5zdGl0dWNpb25hbCBDT05BQ1lUIGxvcyBkZXJlY2hvcyByZXF1ZXJpZG9zIHBvciBlc3RhIGxpY2VuY2lhLCB5IHF1ZSBkaWNobyBtYXRlcmlhbCBkZSBwcm9waWVkYWQgZGUgdGVyY2Vyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8geSByZWNvbm9jaWRvIGRlbnRybyBkZWwgY29udGVuaWRvIGRlIGxhIG9icmEuCgpTaSBsYSBvYnJhIHF1ZSBkZXBvc2l0YSBoYSBzaWRvIHBhdHJvY2luYWRhIG8gZmluYW5jaWFkYSBwb3IgdW5hIG9yZ2FuaXphY2nDs24sIHVzdGVkIGRlY2xhcmEgcXVlIGhhIGN1bXBsaWRvIGNvbiBsYXMgb2JsaWdhY2lvbmVzIHJlcXVlcmlkYXMgcG9yIHRhbCBhY3VlcmRvLgoKU2kgZWwgZG9jdW1lbnRvIHNlIGJhc2EgZW4gdW5hIG9icmEgcXVlIGhhIHNpZG8gcGF0cm9jaW5hZGEgbyBhcG95YWRhIHBvciB1bmEgYWdlbmNpYSB1IG9yZ2FuaXphY2nDs24sIHNlIHByZXN1cG9uZSBxdWUgc2UgaGEgY3VtcGxpZG8gY29uIGN1YWxxdWllciBkZXJlY2hvIGRlIHJldmlzacOzbiB1IG90cmFzIG9ibGlnYWNpb25lcyByZXF1ZXJpZGFzIHBvciBlc3RlIGNvbnRyYXRvIG8gYWN1ZXJkby4KCkVsIFJlcG9zaXRvcmlvIEluc3RpdHVjaW9uYWwgQ09OQUNZVCBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgc3UvcyBub21icmUvcyBjb21vIGVsL2xvcyBhdXRvci9lcyBvIHByb3BpZXRhcmlvL3MgZGUgbG9zIGRlcmVjaG9zIGRlbCBkb2N1bWVudG8sIHkgbm8gaGFyw6EgbmluZ3VuYSBhbHRlcmFjacOzbiBkZSBzdSBkb2N1bWVudG8gZGlmZXJlbnRlIGEgbGFzIHBlcm1pdGlkYXMgZW4gZXN0YSBsaWNlbmNpYS4K |
| spellingShingle | The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis Rolón, Miriam Soledad 7. Salud Antiprotozoal activity Leishmania braziliensis Leishmania infantum Phenolic derivatives Trypanosome cruzi |
| status_str | publishedVersion |
| title | The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis |
| title_full | The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis |
| title_fullStr | The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis |
| title_full_unstemmed | The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis |
| title_short | The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis |
| title_sort | The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis |
| topic | 7. Salud Antiprotozoal activity Leishmania braziliensis Leishmania infantum Phenolic derivatives Trypanosome cruzi |
| url | https://doi.org/10.3855/jidc.10622 http://hdl.handle.net/20.500.14066/4431 |