Host centric drug repurposing for viral diseases
Correspondencia: alberto.paccanaro@rhul.ac.uk.
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| Format: | article |
| Language: | English |
| Published: |
2025
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| Online Access: | https://doi.org/10.1371/journal.pcbi.1012876 http://hdl.handle.net/20.500.14066/4733 |
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| _version_ | 1870885384227913728 |
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| author | de Siqueira Santos, Suzana |
| author2 | Yang, Haixuan Galeano Alfonso, Aldo Javier Paccanaro, Alberto |
| author2_role | author author author |
| author_browse | Galeano Alfonso, Aldo Javier Paccanaro, Alberto Yang, Haixuan de Siqueira Santos, Suzana |
| author_facet | de Siqueira Santos, Suzana Yang, Haixuan Galeano Alfonso, Aldo Javier Paccanaro, Alberto |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/1/Host%20centric%20drug%20repurposing%20for%20viral%20diseases.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/6/journal.pcbi.1012876.s001.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/7/journal.pcbi.1012876.s002.xlsx http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/8/journal.pcbi.1012876.s003.xlsx http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/9/journal.pcbi.1012876.s004.xlsx http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/4/Host%20centric%20drug%20repurposing%20for%20viral%20diseases.pdf.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/10/journal.pcbi.1012876.s001.pdf.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/11/journal.pcbi.1012876.s002.xlsx.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/12/journal.pcbi.1012876.s003.xlsx.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/13/journal.pcbi.1012876.s004.xlsx.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/5/Host%20centric%20drug%20repurposing%20for%20viral%20diseases.jpg |
| dc.contributor.other.es.fl_str_mv | Centro de Ingeniería para la Investigación, Desarrollo e Innovación Tecnológica |
| dc.creator.none.fl_str_mv | de Siqueira Santos, Suzana Yang, Haixuan Galeano Alfonso, Aldo Javier Paccanaro, Alberto |
| dc.date.accessioned.none.fl_str_mv | 2026-01-06T16:15:32Z |
| dc.date.available.none.fl_str_mv | 2026-01-06T16:15:32Z |
| dc.date.issued.none.fl_str_mv | 2025-04-02 |
| dc.format.extent.es.fl_str_mv | 22 páginas |
| dc.identifier.citation.en.fl_str_mv | de Siqueira Santos, S., Yang, H., Galeano, A., & Paccanaro, A. (2025). Host centric drug repurposing for viral diseases. PLoS Computational Biology, 21(4), Artículo e1012876. https://doi.org/10.1371/journal.pcbi.1012876 |
| dc.identifier.doi.es.fl_str_mv | 10.1371/journal.pcbi.1012876 |
| dc.identifier.essn.es.fl_str_mv | 1553-7358 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.1371/journal.pcbi.1012876 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4733 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Public Library of Science |
| dc.relation.projectCONACYT.es.fl_str_mv | PINV01-108 PINV01-719 |
| dc.rights.*.fl_str_mv | Atribución/Reconocimiento 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.es.fl_str_mv | 13. Avance general del conocimiento: I+D financiada con fuentes distintas a los FGU 13.2. I+D relativa a la Ingeniería 13.3. I+D relativa a las Ciencias Médicas |
| dc.subject.ocde.es.fl_str_mv | 3. Ciencias Médicas y de la Salud 3.1. Medicina Básica (anatomía, citología, fisiología, genética, farmacia, farmacología, toxicología, inmunología e inmunohematología, química clínica, microbiología clínica, patología) 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| dc.subject.other.en.fl_str_mv | Antiviral agents Drug discovery Ebolavirus Gene expression Host-pathogen interactions Protein interaction maps Pharmaceutical preparations Gene expression regulation, viral Drug repositioning Virus diseases |
| dc.subject.other.es.fl_str_mv | Antivirales Descubrimiento de drogas Ebolavirus Expresión génica Interacciones huésped-patógeno Mapas de interacción de proteínas Preparaciones farmacéuticas Regulación viral de la expresión génica Reposicionamiento de medicamentos Virosis |
| dc.title.es.fl_str_mv | Host centric drug repurposing for viral diseases |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Correspondencia: alberto.paccanaro@rhul.ac.uk. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_3ca388860e5b36e048e3367588878efe |
| identifier_str_mv | de Siqueira Santos, S., Yang, H., Galeano, A., & Paccanaro, A. (2025). Host centric drug repurposing for viral diseases. PLoS Computational Biology, 21(4), Artículo e1012876. https://doi.org/10.1371/journal.pcbi.1012876 10.1371/journal.pcbi.1012876 1553-7358 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4733 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución/Reconocimiento 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | 9568c36c-1e07-49b0-afb3-8b39563bca02600f604039a-a2be-4c8b-8244-90e9f0576b2260023a4f6a9-8ff3-4e49-a6cd-c24771cc730760024e1bdd6-b0df-48fb-a39e-baec166f788d600Centro de Ingeniería para la Investigación, Desarrollo e Innovación Tecnológica2026-01-06T16:15:32Z2026-01-06T16:15:32Z2025-04-02de Siqueira Santos, S., Yang, H., Galeano, A., & Paccanaro, A. (2025). Host centric drug repurposing for viral diseases. PLoS Computational Biology, 21(4), Artículo e1012876. https://doi.org/10.1371/journal.pcbi.1012876https://doi.org/10.1371/journal.pcbi.1012876http://hdl.handle.net/20.500.14066/473310.1371/journal.pcbi.10128761553-7358Correspondencia: alberto.paccanaro@rhul.ac.uk.Computational approaches for drug repurposing for viral diseases have mainly focused on a small number of antivirals that directly target pathogens (virus centric therapies). In this work, we combine ideas from collaborative filtering and network medicine for making predictions on a much larger set of drugs that could be repurposed for host centric therapies, that are aimed at interfering with host cell factors required by a pathogen. Our idea is to create matrices quantifying the perturbation that drugs and viruses induce on human protein interaction networks. Then, we decompose these matrices to learn embeddings of drugs, viruses, and proteins in a low dimensional space. Predictions of host-centric antivirals are obtained by taking the dot product between the corresponding drug and virus representations. Our approach is general and can be applied systematically to any compound with known targets and any virus whose host proteins are known. We show that our predictions have high accuracy and that the embeddings contain meaningful biological information that may provide insights into the underlying biology of viral infections. Our approach can integrate different types of information, does not rely on known drug-virus associations and can be applied to new viral diseases and drugs.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrollo22 páginasengPublic Library of ScienceAtribución/Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2025 de Siqueira Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.13. Avance general del conocimiento: I+D financiada con fuentes distintas a los FGU13.2. I+D relativa a la Ingeniería13.3. I+D relativa a las Ciencias MédicasAntiviralesDescubrimiento de drogasEbolavirusExpresión génicaInteracciones huésped-patógenoMapas de interacción de proteínasPreparaciones farmacéuticasRegulación viral de la expresión génicaReposicionamiento de medicamentosVirosisAntiviral agentsDrug discoveryEbolavirusGene expressionHost-pathogen interactionsProtein interaction mapsPharmaceutical preparationsGene expression regulation, viralDrug repositioningVirus diseases3. Ciencias Médicas y de la Salud3.1. Medicina Básica (anatomía, citología, fisiología, genética, farmacia, farmacología, toxicología, inmunología e inmunohematología, química clínica, microbiología clínica, patología)3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología)Host centric drug repurposing for viral diseasesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4PLOS Computational BiologyPINV01-108PINV01-71921de Siqueira Santos, SuzanaYang, HaixuanGaleano Alfonso, Aldo JavierPaccanaro, AlbertoORIGINALHost centric drug repurposing for viral diseases.pdfHost centric drug repurposing for viral diseases.pdfArtículo científicoapplication/pdf1969894http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/1/Host%20centric%20drug%20repurposing%20for%20viral%20diseases.pdf8850241314ea064d60882c068591e5caMD51journal.pcbi.1012876.s001.pdfjournal.pcbi.1012876.s001.pdfTexto S1. Notas suplementariasapplication/pdf871784http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4733/6/journal.pcbi.1012876.s001.pdf44af7e2b3002caac937ae6bfb016ccf9MD56journal.pcbi.1012876.s002.xlsxjournal.pcbi.1012876.s002.xlsxArchivo S1. 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| spellingShingle | Host centric drug repurposing for viral diseases de Siqueira Santos, Suzana 13. Avance general del conocimiento: I+D financiada con fuentes distintas a los FGU 13.2. I+D relativa a la Ingeniería 13.3. I+D relativa a las Ciencias Médicas Antivirales Descubrimiento de drogas Ebolavirus Expresión génica Interacciones huésped-patógeno Mapas de interacción de proteínas Preparaciones farmacéuticas Regulación viral de la expresión génica Reposicionamiento de medicamentos Virosis Antiviral agents Drug discovery Ebolavirus Gene expression Host-pathogen interactions Protein interaction maps Pharmaceutical preparations Gene expression regulation, viral Drug repositioning Virus diseases 3. Ciencias Médicas y de la Salud 3.1. Medicina Básica (anatomía, citología, fisiología, genética, farmacia, farmacología, toxicología, inmunología e inmunohematología, química clínica, microbiología clínica, patología) 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| status_str | publishedVersion |
| title | Host centric drug repurposing for viral diseases |
| title_full | Host centric drug repurposing for viral diseases |
| title_fullStr | Host centric drug repurposing for viral diseases |
| title_full_unstemmed | Host centric drug repurposing for viral diseases |
| title_short | Host centric drug repurposing for viral diseases |
| title_sort | Host centric drug repurposing for viral diseases |
| topic | 13. Avance general del conocimiento: I+D financiada con fuentes distintas a los FGU 13.2. I+D relativa a la Ingeniería 13.3. I+D relativa a las Ciencias Médicas Antivirales Descubrimiento de drogas Ebolavirus Expresión génica Interacciones huésped-patógeno Mapas de interacción de proteínas Preparaciones farmacéuticas Regulación viral de la expresión génica Reposicionamiento de medicamentos Virosis Antiviral agents Drug discovery Ebolavirus Gene expression Host-pathogen interactions Protein interaction maps Pharmaceutical preparations Gene expression regulation, viral Drug repositioning Virus diseases 3. Ciencias Médicas y de la Salud 3.1. Medicina Básica (anatomía, citología, fisiología, genética, farmacia, farmacología, toxicología, inmunología e inmunohematología, química clínica, microbiología clínica, patología) 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| url | https://doi.org/10.1371/journal.pcbi.1012876 http://hdl.handle.net/20.500.14066/4733 |