In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract
Correspondence: lukenrol@qui.una.py or mkennedy.rolon@gmail.com
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| Other Authors: | , , , , |
| Format: | article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://doi.org/10.3390/molecules27227828 http://hdl.handle.net/20.500.14066/4376 |
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| _version_ | 1870612068108861440 |
|---|---|
| author | Taboada, Teresa |
| author2 | Alvarenga Sosa, Nelson Luis Galeano, Antonia K. Arrúa, Wilfrido J. Campuzano Bublitz, Miguel Ángel Kennedy, María L. |
| author2_role | author author author author author |
| author_browse | Alvarenga Sosa, Nelson Luis Arrúa, Wilfrido J. Campuzano Bublitz, Miguel Ángel Galeano, Antonia K. Kennedy, María L. Taboada, Teresa |
| author_facet | Taboada, Teresa Alvarenga Sosa, Nelson Luis Galeano, Antonia K. Arrúa, Wilfrido J. Campuzano Bublitz, Miguel Ángel Kennedy, María L. |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 MD5 MD5 |
| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/1/In%20vivo%20antidepressant-like%20effect%20assessment%20of%20two%20Aloysia%20species.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/4/In%20vivo%20antidepressant-like%20effect%20assessment%20of%20two%20Aloysia%20species.pdf.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/5/In%20vivo%20antidepressant-like%20effect%20assessment%20of%20two%20Aloysia%20species.jpg |
| dc.contributor.other.es.fl_str_mv | Universidad Nacional de Asunción. Facultad de Ciencias Químicas |
| dc.creator.none.fl_str_mv | Taboada, Teresa Alvarenga Sosa, Nelson Luis Galeano, Antonia K. Arrúa, Wilfrido J. Campuzano Bublitz, Miguel Ángel Kennedy, María L. |
| dc.date.accessioned.none.fl_str_mv | 2024-02-29T01:31:58Z |
| dc.date.available.none.fl_str_mv | 2024-02-29T01:31:58Z |
| dc.date.issued.none.fl_str_mv | 2022-11-13 |
| dc.format.extent.es.fl_str_mv | 16 páginas |
| dc.identifier.citation.en.fl_str_mv | Taboada, T.; Alvarenga, N.L.; Galeano, A.K.; Arrúa,W.J.; Campuzano Bublitz, M.A.; Kennedy, M.L. In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract. Molecules 2022, 27, 7828. https://doi.org/10.3390/molecules27227828 |
| dc.identifier.doi.es.fl_str_mv | 10.3390/molecules27227828 |
| dc.identifier.essn.es.fl_str_mv | 1420-3049 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.3390/molecules27227828 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4376 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Multidisciplinary Digital Publishing Institute |
| dc.relation.projectCONACYT.es.fl_str_mv | POSG17-61 BNAC03-26 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.es.fl_str_mv | 7. Salud |
| dc.subject.other.es.fl_str_mv | Aloysia gratissima var. gratissima Aloysia virgata var. platyphylla Depression Forced swimming test Tail suspension test |
| dc.title.es.fl_str_mv | In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Correspondence: lukenrol@qui.una.py or mkennedy.rolon@gmail.com |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_5fb345b7362fefa6a3cb1b9b7e280cda |
| identifier_str_mv | Taboada, T.; Alvarenga, N.L.; Galeano, A.K.; Arrúa,W.J.; Campuzano Bublitz, M.A.; Kennedy, M.L. In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract. Molecules 2022, 27, 7828. https://doi.org/10.3390/molecules27227828 10.3390/molecules27227828 1420-3049 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4376 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | ce0ec49a-9da6-4394-bc20-f8039d12befd600466000000-0002-7949-7341120eaaca-e267-4805-a13e-77a6e127ddb060030bbd834-1ad8-46bc-b8bc-c9aad74f881e6002365005d3d37b1-9f82-4565-93f7-2b78abc84ed3600Universidad Nacional de Asunción. Facultad de Ciencias Químicas2024-02-29T01:31:58Z2024-02-29T01:31:58Z2022-11-13Taboada, T.; Alvarenga, N.L.; Galeano, A.K.; Arrúa,W.J.; Campuzano Bublitz, M.A.; Kennedy, M.L. In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract. Molecules 2022, 27, 7828. https://doi.org/10.3390/molecules27227828https://doi.org/10.3390/molecules27227828http://hdl.handle.net/20.500.14066/437610.3390/molecules272278281420-3049Correspondence: lukenrol@qui.una.py or mkennedy.rolon@gmail.comMedicinal plants belonging to the Verbenaceae family demonstrated antidepressant effects in preclinical studies. Depression is one of the largest contributors to the global health burden of all countries. Plants from the Aloysia genus are traditionally used for affective disorders, and some of them have proven anxiolytic and antidepressant activity. The aim of this work was to evaluate the antidepressant effect of the ethanolic extract of Aloysia gratissima var. gratissima (Agg) and Aloysia virgata var. platyphylla (Avp) in mice. A tail suspension test (TST) and forced swimming test (FST) were conducted after three doses in a period of 24 h and after 7 days of treatment. Imipramine was used as an antidepressant drug. The main results demonstrated that Agg extract reduced the immobility time in mice treated orally for 7 consecutive days when compared to the control group (reduced by about 77%, imipramine 70%). Animals treated with three doses of Avp in a 24-h period had reduced immobility time in the FST (60%), and after 7 days of treatment the reduction was greater (Avp 50, 100, and 200 about 85%; Avp 400, 96.5%; p < 0.0001, imipramine, 77%). LCMS analysis showed the presence of verbascoside, hoffmaniaketone, and hoffmaniaketone acetate in both, A. virgata var. platyphylla and A. gratissima var gratissima. The flavonoids nepetin and 6-hydroxyluteolin were also found in Agg. Both tested extracts demonstrated promising antidepressant-like activity in mice.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de creación y fortalecimiento de maestrías y doctorados de excelenciaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Incentivos para la formación de investigadores en postgrados nacionales16 páginasengMultidisciplinary Digital Publishing InstituteAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).7. SaludAloysia gratissima var. gratissimaAloysia virgata var. platyphyllaDepressionForced swimming testTail suspension testIn vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extractinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion22MoleculesPOSG17-61BNAC03-2627Taboada, TeresaAlvarenga Sosa, Nelson LuisGaleano, Antonia K.Arrúa, Wilfrido J.Campuzano Bublitz, Miguel ÁngelKennedy, María L.ORIGINALIn vivo antidepressant-like effect assessment of two Aloysia species.pdfIn vivo antidepressant-like effect assessment of two Aloysia species.pdfArtículo científicoapplication/pdf3721222http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/1/In%20vivo%20antidepressant-like%20effect%20assessment%20of%20two%20Aloysia%20species.pdfd52634d9d733901857c090dbb36215aaMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/2/license_rdf0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/3/license.txt858b22fda432bd774e469302988c1974MD53TEXTIn vivo antidepressant-like effect assessment of two Aloysia species.pdf.txtIn vivo antidepressant-like effect assessment of two Aloysia species.pdf.txtExtracted texttext/plain59396http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/4/In%20vivo%20antidepressant-like%20effect%20assessment%20of%20two%20Aloysia%20species.pdf.txtc52c311d340a0af477288d62771390d0MD54THUMBNAILIn vivo antidepressant-like effect assessment of two Aloysia species.jpgIn vivo antidepressant-like effect assessment of two Aloysia species.jpgPortadaimage/jpeg943757http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4376/5/In%20vivo%20antidepressant-like%20effect%20assessment%20of%20two%20Aloysia%20species.jpg4d46b3567906cca7aa124594925f9b58MD5520.500.14066/4376oai:repositorio.conacyt.gov.py:20.500.14066/43762026-02-12 19:30:35.422Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.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 |
| spellingShingle | In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract Taboada, Teresa 7. Salud Aloysia gratissima var. gratissima Aloysia virgata var. platyphylla Depression Forced swimming test Tail suspension test |
| status_str | publishedVersion |
| title | In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract |
| title_full | In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract |
| title_fullStr | In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract |
| title_full_unstemmed | In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract |
| title_short | In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract |
| title_sort | In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract |
| topic | 7. Salud Aloysia gratissima var. gratissima Aloysia virgata var. platyphylla Depression Forced swimming test Tail suspension test |
| url | https://doi.org/10.3390/molecules27227828 http://hdl.handle.net/20.500.14066/4376 |