Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay
Corresponding authors: Alejandra Rojas, alerojaspy@gmail.com; Jesse Waggoner, jesse.waggoner@emoryhealthcare.org
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| Формат: | article |
| Мова: | Англійська |
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2019
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| Онлайн доступ: | https://doi.org/10.7717/peerj.7852 http://hdl.handle.net/20.500.14066/4373 |
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| _version_ | 1870885385733668864 |
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| author | Rojas Segovia, Alejandra María |
| author2 | Cardozo Segovia, Fátima María Cantero, César Stittleburg, Victoria López, Sanny Bernal, Cynthia Giménez Acosta, Francisco Eugenio Mendoza Torres, Laura Patricia Pinsky, Benjamin A. Arévalo de Guillén, Ivalena Páez Acchiardi, Gloria Malvina Waggoner, Jesse J. |
| author2_role | author author author author author author author author author author author |
| author_browse | Arévalo de Guillén, Ivalena Bernal, Cynthia Cantero, César Cardozo Segovia, Fátima María Giménez Acosta, Francisco Eugenio López, Sanny Mendoza Torres, Laura Patricia Pinsky, Benjamin A. Páez Acchiardi, Gloria Malvina Rojas Segovia, Alejandra María Stittleburg, Victoria Waggoner, Jesse J. |
| author_facet | Rojas Segovia, Alejandra María Cardozo Segovia, Fátima María Cantero, César Stittleburg, Victoria López, Sanny Bernal, Cynthia Giménez Acosta, Francisco Eugenio Mendoza Torres, Laura Patricia Pinsky, Benjamin A. Arévalo de Guillén, Ivalena Páez Acchiardi, Gloria Malvina Waggoner, Jesse J. |
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| dc.creator.none.fl_str_mv | Rojas Segovia, Alejandra María Cardozo Segovia, Fátima María Cantero, César Stittleburg, Victoria López, Sanny Bernal, Cynthia Giménez Acosta, Francisco Eugenio Mendoza Torres, Laura Patricia Pinsky, Benjamin A. Arévalo de Guillén, Ivalena Páez Acchiardi, Gloria Malvina Waggoner, Jesse J. |
| dc.date.accessioned.none.fl_str_mv | 2024-02-27T13:26:37Z |
| dc.date.available.none.fl_str_mv | 2024-02-27T13:26:37Z |
| dc.date.issued.none.fl_str_mv | 2019-10-09 |
| dc.format.extent.es.fl_str_mv | 20 páginas |
| dc.identifier.citation.en.fl_str_mv | Rojas A, Cardozo F, Cantero C, Stittleburg V, López S, Bernal C, Gimenez Acosta FE, Mendoza L, Pinsky BA, Arévalo de Guillén I, Páez M, Waggoner J. 2019. Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay. PeerJ 7:e7852 http://doi.org/10.7717/peerj.7852 |
| dc.identifier.doi.es.fl_str_mv | 10.7717/peerj.7852 |
| dc.identifier.essn.es.fl_str_mv | 2167-8359 |
| dc.identifier.other.none.fl_str_mv | https://doi.org/10.7717/peerj.7852 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4373 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | PeerJ Inc. |
| dc.relation.projectCONACYT.*.fl_str_mv | PVCT16-66 PVCT17-65 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.copyright.es.fl_str_mv | © 2019 Rojas et al. Distributed under Creative Commons CC-BY 4.0 |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.es.fl_str_mv | 7. Salud |
| dc.subject.other.es.fl_str_mv | Anti-NS1 antibody Dengue virus Diagnosis Epidemiology Global health Hospitalization Infectious diseases NS1 RT-PCR Viral load |
| dc.title.es.fl_str_mv | Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Corresponding authors: Alejandra Rojas, alerojaspy@gmail.com; Jesse Waggoner, jesse.waggoner@emoryhealthcare.org |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_60b47b304614d6e999976ebe6ae6046f |
| identifier_str_mv | Rojas A, Cardozo F, Cantero C, Stittleburg V, López S, Bernal C, Gimenez Acosta FE, Mendoza L, Pinsky BA, Arévalo de Guillén I, Páez M, Waggoner J. 2019. Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay. PeerJ 7:e7852 http://doi.org/10.7717/peerj.7852 10.7717/peerj.7852 2167-8359 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4373 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
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| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ © 2019 Rojas et al. Distributed under Creative Commons CC-BY 4.0 |
| spelling | 1002600259600ac972c34-6e43-4caa-a5df-3b2142448990600688adc46-8045-48c4-9cb4-e4f379cb8e786007b312be8-a290-41fc-9ef8-9338f29f2765600142c16ce-dd78-4237-b975-aaa64a424ff9600b063b40d-d64f-4201-89c4-af45a54510286007426000000-0001-6124-1244bb370a93-63ed-4720-a616-649a6874ed2b600776008566002d504966-0a96-4d8c-8e00-c59a6d0a06096002024-02-27T13:26:37Z2024-02-27T13:26:37Z2019-10-09Rojas A, Cardozo F, Cantero C, Stittleburg V, López S, Bernal C, Gimenez Acosta FE, Mendoza L, Pinsky BA, Arévalo de Guillén I, Páez M, Waggoner J. 2019. Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay. PeerJ 7:e7852 http://doi.org/10.7717/peerj.7852https://doi.org/10.7717/peerj.7852http://hdl.handle.net/20.500.14066/437310.7717/peerj.78522167-8359Corresponding authors: Alejandra Rojas, alerojaspy@gmail.com; Jesse Waggoner, jesse.waggoner@emoryhealthcare.orgBackground. In 2018, Paraguay experienced a large dengue virus (DENV) outbreak. The primary objective of this study was to characterize dengue cases in the Central Department, where the majority of cases occur, and identify factors associated with DENV infection. Methods. Patients were enrolled from January-May 2018 if they presented with a suspected arboviral illness. Acute-phase specimens (≤8 days after symptom onset) were tested using rRT-PCR, a rapid diagnostic test for DENV nonstructural protein 1 (NS1) and anti-DENV IgM and IgG, and ELISA for IgG against NS1 from Zika virus (ZIKV). Results. A total of 231 patients were enrolled (95.2% adults) at two sites: emergency care and an outpatient clinical site. Patients included 119 (51.5%) dengue cases confirmed by rRT-PCR (n = 115, 96.6%) and/or the detection of NS1 and anti-DENV IgM (n = 4, 3.4%). DENV-1 was the predominant serotype (109/115, 94.8%). Epidemiologically, dengue cases and non-dengue cases were similar, though dengue cases were less likely to reside in a house/apartment or report a previous dengue case. Clinical and laboratory findings associated with dengue included red eyes, absence of sore throat, leucopenia and thrombocytopenia. At an emergency care site, 26% of dengue cases (26/100) required hospitalization. In univariate analysis, hospitalization was associated with increased viral load, anti-DENV IgG, and thrombocytopenia. Among dengue cases that tested positive for IgG against ZIKV NS1, the odds of DENV NS1 detection in the acute phase were decreased 10-fold (OR 0.1, 0.0–0.3). Conclusions. Findings from a predominantly adult population demonstrate clinical and laboratory factors associated with DENV infections and the potential severity of dengue in this group. The combination of viral load and specific IgG antibodies warrant further study as a prognostic to identify patients at risk for severe disease.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Financiamiento para la vinculación de científicos y tecnólogos20 páginasengPeerJ Inc.Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2019 Rojas et al. Distributed under Creative Commons CC-BY 4.07. SaludAnti-NS1 antibodyDengue virusDiagnosisEpidemiologyGlobal healthHospitalizationInfectious diseasesNS1RT-PCRViral loadCharacterization of dengue cases among patients with an acute illness, Central Department, Paraguayinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeerJPVCT16-66PVCT17-65Rojas Segovia, Alejandra MaríaCardozo Segovia, Fátima MaríaCantero, CésarStittleburg, VictoriaLópez, SannyBernal, CynthiaGiménez Acosta, Francisco EugenioMendoza Torres, Laura PatriciaPinsky, Benjamin A.Arévalo de Guillén, IvalenaPáez Acchiardi, Gloria MalvinaWaggoner, Jesse J.ORIGINALCharacterization of dengue cases among.pdfCharacterization of dengue cases among.pdfArtículo científicoapplication/pdf962075http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4373/1/Characterization%20of%20dengue%20cases%20among.pdf116f19c95f1681719ebe6be985c7138fMD51PeerJ_Raw_Data.xlsxPeerJ_Raw_Data.xlsxAnexo I. 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| spellingShingle | Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay Rojas Segovia, Alejandra María 7. Salud Anti-NS1 antibody Dengue virus Diagnosis Epidemiology Global health Hospitalization Infectious diseases NS1 RT-PCR Viral load |
| status_str | publishedVersion |
| title | Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay |
| title_full | Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay |
| title_fullStr | Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay |
| title_full_unstemmed | Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay |
| title_short | Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay |
| title_sort | Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay |
| topic | 7. Salud Anti-NS1 antibody Dengue virus Diagnosis Epidemiology Global health Hospitalization Infectious diseases NS1 RT-PCR Viral load |
| url | https://doi.org/10.7717/peerj.7852 http://hdl.handle.net/20.500.14066/4373 |