Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice
Corresponding Author: María L. Kennedy, Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Campus UNA, San Lorenzo, Paraguay. E-mail: lukenrol@qui.una.py
Պահպանված է:
| Հիմնական հեղինակ: | |
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| Այլ հեղինակներ: | , , , |
| Ձևաչափ: | article |
| Լեզու: | անգլերեն |
| Հրապարակվել է: |
2019
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| Խորագրեր: | |
| Առցանց հասանելիություն: | http://hdl.handle.net/20.500.14066/4460 |
| Ցուցիչներ: |
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1870612068388831232 |
|---|---|
| author | Soverina Escobar, María Soledad |
| author2 | Campuzano Bublitz, Miguel Ángel Centurión Quintana, Juan Rafael Galeano, Antonia K. Kennedy Rolón, María Luisa |
| author2_role | author author author author |
| author_browse | Campuzano Bublitz, Miguel Ángel Centurión Quintana, Juan Rafael Galeano, Antonia K. Kennedy Rolón, María Luisa Soverina Escobar, María Soledad |
| author_facet | Soverina Escobar, María Soledad Campuzano Bublitz, Miguel Ángel Centurión Quintana, Juan Rafael Galeano, Antonia K. Kennedy Rolón, María Luisa |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 MD5 MD5 |
| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/1/Preliminary%20evaluation%20of%20hepatoprotective%20and%20nephroprotective.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/4/Preliminary%20evaluation%20of%20hepatoprotective%20and%20nephroprotective.jpg http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/5/Preliminary%20evaluation%20of%20hepatoprotective%20and%20nephroprotective.pdf.txt |
| dc.contributor.other.es.fl_str_mv | Universidad Nacional de Asunción. Facultad de Ciencias Químicas |
| dc.creator.none.fl_str_mv | Soverina Escobar, María Soledad Campuzano Bublitz, Miguel Ángel Centurión Quintana, Juan Rafael Galeano, Antonia K. Kennedy Rolón, María Luisa |
| dc.date.accessioned.none.fl_str_mv | 2024-08-27T14:27:22Z |
| dc.date.available.none.fl_str_mv | 2024-08-27T14:27:22Z |
| dc.date.issued.none.fl_str_mv | 2019-12-03 |
| dc.identifier.citation.en.fl_str_mv | Soverina, M. S., Campuzano Bublitz, M. A., Centurión, J. R., Galeano, A. K., & Kennedy, M. L. (2019). Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia leaf extract in mice. Journal of Applied Pharmaceutical Science, 9(12), 37-41. https://doi.org/10.7324/JAPS.2019.91206 |
| dc.identifier.doi.es.fl_str_mv | 10.7324/JAPS.2019.91206 |
| dc.identifier.essn.es.fl_str_mv | 2231-3354 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4460 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Open Science Publishers LLP |
| dc.relation.projectCONACYT.es.fl_str_mv | PINV15-378 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.en.fl_str_mv | 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations |
| dc.subject.classification.es.fl_str_mv | 6. Producción y tecnología industrial |
| dc.subject.ocde.es.fl_str_mv | 1. Ciencias Naturales 1.3. Ciencias Químicas (Química, otras áreas afines) |
| dc.subject.other.es.fl_str_mv | Acetaminophen Creatinine Gentamicin Mice Prosopis ruscifolia Transaminases |
| dc.title.es.fl_str_mv | Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Corresponding Author: María L. Kennedy, Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Campus UNA, San Lorenzo, Paraguay. E-mail: lukenrol@qui.una.py |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_6560b0642b83a4e58c07346b5cd1590a |
| identifier_str_mv | Soverina, M. S., Campuzano Bublitz, M. A., Centurión, J. R., Galeano, A. K., & Kennedy, M. L. (2019). Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia leaf extract in mice. Journal of Applied Pharmaceutical Science, 9(12), 37-41. https://doi.org/10.7324/JAPS.2019.91206 10.7324/JAPS.2019.91206 2231-3354 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4460 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | 32759fd7-f252-4762-beba-2581008648f46002366004dba589f-f11d-4a4c-9f30-319d1a348f24600120eaaca-e267-4805-a13e-77a6e127ddb0600632600Universidad Nacional de Asunción. Facultad de Ciencias Químicas2024-08-27T14:27:22Z2024-08-27T14:27:22Z2019-12-03Soverina, M. S., Campuzano Bublitz, M. A., Centurión, J. R., Galeano, A. K., & Kennedy, M. L. (2019). Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia leaf extract in mice. Journal of Applied Pharmaceutical Science, 9(12), 37-41. https://doi.org/10.7324/JAPS.2019.91206http://hdl.handle.net/20.500.14066/446010.7324/JAPS.2019.912062231-3354Corresponding Author: María L. Kennedy, Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Campus UNA, San Lorenzo, Paraguay. E-mail: lukenrol@qui.una.pyLiver and kidney are vital organs for body homeostasis and are exposed to damage or injury of various origins. Many medicinal plants have proved to be effective for hepatic and renal diseases. This study aimed to test the effect of Prosopis ruscifolia Griseb. leaves extract on acetaminophen-induced hepatotoxicity and gentamicin-induced nephrotoxicity. The experiment was carried out in mice, 300 mg/kg of acetaminophen, i.p., and 135 mg/kg of gentamicin were used to induce liver and kidney damage, respectively. Silymarin was used as protective control drug. For estimating the liver function, alkaline phosphatase (ALP), aspartate aminotransferase (AST or GOT), and alanine aminotransferase (ALT or GPT) were measured; and creatinine, urea, and uric acid were determined in order to verify kidney functionality. The results showed that the extract has both hepatoprotective and nephroprotective effect. This is evidenced by reduced values of the level of GOT, GPT, and ALP, in mice co-administered, p.o., with P. ruscifolia; and by the reduction of serum creatinine in mice with gentamicin induced kidney damage. These values showed statistically significant difference when compared with those of pathological group. The alcoholic extract of P. ruscifolia denoted hepatoprotective and nephroprotective effects.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloengOpen Science Publishers LLPAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2019 María S. Soverina et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations6. Producción y tecnología industrialAcetaminophenCreatinineGentamicinMiceProsopis ruscifoliaTransaminases1. Ciencias Naturales1.3. Ciencias Químicas (Química, otras áreas afines)Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in miceinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12Journal of Applied Pharmaceutical Science3741PINV15-3789Soverina Escobar, María SoledadCampuzano Bublitz, Miguel ÁngelCenturión Quintana, Juan RafaelGaleano, Antonia K.Kennedy Rolón, María LuisaORIGINALPreliminary evaluation of hepatoprotective and nephroprotective.pdfPreliminary evaluation of hepatoprotective and nephroprotective.pdfArtículo científicoapplication/pdf451351http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/1/Preliminary%20evaluation%20of%20hepatoprotective%20and%20nephroprotective.pdf30f8548f43bd0e5b44bfc75e668a43b9MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/2/license_rdf0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/3/license.txt858b22fda432bd774e469302988c1974MD53THUMBNAILPreliminary evaluation of hepatoprotective and nephroprotective.jpgPreliminary evaluation of hepatoprotective and nephroprotective.jpgPortadaimage/jpeg1023201http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/4/Preliminary%20evaluation%20of%20hepatoprotective%20and%20nephroprotective.jpg11f78b54c72a6d8ee6990401e82c661cMD54TEXTPreliminary evaluation of hepatoprotective and nephroprotective.pdf.txtPreliminary evaluation of hepatoprotective and nephroprotective.pdf.txtExtracted texttext/plain23962http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4460/5/Preliminary%20evaluation%20of%20hepatoprotective%20and%20nephroprotective.pdf.txt5f2862395d58b74fd99e070677f66693MD5520.500.14066/4460oai:repositorio.conacyt.gov.py:20.500.14066/44602026-02-12 19:30:37.934Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.pyQWwgYWNlcHRhciBlc3RhIGxpY2VuY2lhLCB1c3RlZCBjb21vIGF1dG9yIHkgcHJvcGlldGFyaW8gZGUgbG9zIGRlcmVjaG9zIGRlIHByb3BpZWRhZCBpbnRlbGVjdHVhbCBkZSBzdSBvYnJhIG90b3JnYSBhbCBSZXBvc2l0b3JpbyBJbnN0aXR1Y2lvbmFsIENPTkFDWVQgZWwgZGVyZWNobyBubyBleGNsdXNpdm8gZGUgcmVwcm9kdWNjacOzbiB5IGRpc3RyaWJ1Y2nDs24gZGUgc3Ugb2JyYSBlbiBjdWFscXVpZXIgZm9ybWF0byB5IG1lZGlvLgoKQWNlcHRhIHF1ZSwgc2luIG1vZGlmaWNhciBlbCBjb250ZW5pZG8sIHNlIHB1ZWRhIGNvbnZlcnRpciBzdSBvYnJhIGEgb3RybyBmb3JtYXRvIGNvbiBmaW5lcyBkZSBwcmVzZXJ2YWNpw7NuLiBBc8OtIG1pc21vLCBhY2VwdGEgcXVlIHNlIHB1ZWRhIGNvbnNlcnZhciBtw6FzIGRlIHVuYSBjb3BpYSBwb3IgbW90aXZvcyBkZSBzZWd1cmlkYWQgeSBwcmVzZXJ2YWNpw7NuLgoKVXN0ZWQgZGVjbGFyYSBxdWUgZWwgdHJhYmFqbyBwcmVzZW50YWRvIGVzIG9yaWdpbmFsIHkgcXVlIGN1ZW50YSBjb24gbGEgcG90ZXN0YWQgcGFyYSBvdG9yZ2FyIGxvcyBkZXJlY2hvcyBkZXRhbGxhZG9zIGVuIGVzdGEgbGljZW5jaWEuIFRhbWJpw6luIGRlY2xhcmEgcXVlIHN1IG9icmEgbm8gaW5mcmluZ2UgbG8gZXN0YWJsZWNpZG8gZW4gbGEgdmlnZW50ZSBsZWdpc2xhY2nDs24gc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsLgoKU2kgbGEgb2JyYSBjb250aWVuZSBtYXRlcmlhbCBwYXJhIGVsIGN1YWwgbm8gdGllbmUgZGVyZWNob3MgZGUgYXV0b3IsIHVzdGVkIGRlY2xhcmEgcXVlIGhhIG9idGVuaWRvIGxvcyBwZXJtaXNvcyBuZWNlc2FyaW9zIGRlbCBwcm9waWV0YXJpbyBwYXJhIG90b3JnYXIgYWwgUmVwb3NpdG9yaW8gSW5zdGl0dWNpb25hbCBDT05BQ1lUIGxvcyBkZXJlY2hvcyByZXF1ZXJpZG9zIHBvciBlc3RhIGxpY2VuY2lhLCB5IHF1ZSBkaWNobyBtYXRlcmlhbCBkZSBwcm9waWVkYWQgZGUgdGVyY2Vyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8geSByZWNvbm9jaWRvIGRlbnRybyBkZWwgY29udGVuaWRvIGRlIGxhIG9icmEuCgpTaSBsYSBvYnJhIHF1ZSBkZXBvc2l0YSBoYSBzaWRvIHBhdHJvY2luYWRhIG8gZmluYW5jaWFkYSBwb3IgdW5hIG9yZ2FuaXphY2nDs24sIHVzdGVkIGRlY2xhcmEgcXVlIGhhIGN1bXBsaWRvIGNvbiBsYXMgb2JsaWdhY2lvbmVzIHJlcXVlcmlkYXMgcG9yIHRhbCBhY3VlcmRvLgoKU2kgZWwgZG9jdW1lbnRvIHNlIGJhc2EgZW4gdW5hIG9icmEgcXVlIGhhIHNpZG8gcGF0cm9jaW5hZGEgbyBhcG95YWRhIHBvciB1bmEgYWdlbmNpYSB1IG9yZ2FuaXphY2nDs24sIHNlIHByZXN1cG9uZSBxdWUgc2UgaGEgY3VtcGxpZG8gY29uIGN1YWxxdWllciBkZXJlY2hvIGRlIHJldmlzacOzbiB1IG90cmFzIG9ibGlnYWNpb25lcyByZXF1ZXJpZGFzIHBvciBlc3RlIGNvbnRyYXRvIG8gYWN1ZXJkby4KCkVsIFJlcG9zaXRvcmlvIEluc3RpdHVjaW9uYWwgQ09OQUNZVCBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgc3UvcyBub21icmUvcyBjb21vIGVsL2xvcyBhdXRvci9lcyBvIHByb3BpZXRhcmlvL3MgZGUgbG9zIGRlcmVjaG9zIGRlbCBkb2N1bWVudG8sIHkgbm8gaGFyw6EgbmluZ3VuYSBhbHRlcmFjacOzbiBkZSBzdSBkb2N1bWVudG8gZGlmZXJlbnRlIGEgbGFzIHBlcm1pdGlkYXMgZW4gZXN0YSBsaWNlbmNpYS4K |
| spellingShingle | Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice Soverina Escobar, María Soledad 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations 6. Producción y tecnología industrial Acetaminophen Creatinine Gentamicin Mice Prosopis ruscifolia Transaminases 1. Ciencias Naturales 1.3. Ciencias Químicas (Química, otras áreas afines) |
| status_str | publishedVersion |
| title | Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice |
| title_full | Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice |
| title_fullStr | Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice |
| title_full_unstemmed | Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice |
| title_short | Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice |
| title_sort | Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice |
| topic | 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations 6. Producción y tecnología industrial Acetaminophen Creatinine Gentamicin Mice Prosopis ruscifolia Transaminases 1. Ciencias Naturales 1.3. Ciencias Químicas (Química, otras áreas afines) |
| url | http://hdl.handle.net/20.500.14066/4460 |