High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay
Correspondencia: bobadillaml@gmail.com.
Furkejuvvon:
| Váldodahkki: | |
|---|---|
| Eará dahkkit: | , , , |
| Materiálatiipa: | article |
| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
2023
|
| Fáttát: | |
| Liŋkkat: | https://doi.org/10.1371/journal.pone.0283542 http://hdl.handle.net/20.500.14066/4654 |
| Fáddágilkorat: |
Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!
|
| _version_ | 1870612068869079040 |
|---|---|
| author | Bobadilla Frizzola, María Liz |
| author2 | Villagra Carrón, Verónica Ortiz, Violeta Deluca, Gerardo Salete de Paula, Vanessa |
| author2_role | author author author author |
| author_browse | Bobadilla Frizzola, María Liz Deluca, Gerardo Ortiz, Violeta Salete de Paula, Vanessa Villagra Carrón, Verónica |
| author_facet | Bobadilla Frizzola, María Liz Villagra Carrón, Verónica Ortiz, Violeta Deluca, Gerardo Salete de Paula, Vanessa |
| author_role | author |
| bitstream.checksum.fl_str_mv | ae7cdafcecd0b19764409cc0a9a05c15 f6642ec91cd24cd058c338f50db50ef0 0175ea4a2d4caec4bbcc37e300941108 858b22fda432bd774e469302988c1974 835017b81cd3db9003cefa16cf7472fb |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 MD5 MD5 |
| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/1/High%20prevalence%20and%20co-infection%20of%20high-risk%20Human%20Papillomavirus%20genotypes%20among%20unvaccinated%20young%20women%20from%20Paraguay.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/4/High%20prevalence%20and%20co-infection%20of%20high-risk%20Human%20Papillomavirus%20genotypes%20among%20unvaccinated%20young%20women%20from%20Paraguay.jpg http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/5/High%20prevalence%20and%20co-infection%20of%20high-risk%20Human%20Papillomavirus%20genotypes%20among%20unvaccinated%20young%20women%20from%20Paraguay.pdf.txt |
| dc.contributor.other.es.fl_str_mv | Ministerio de Salud Pública y Bienestar Social. Laboratorio Central de Salud Pública |
| dc.creator.none.fl_str_mv | Bobadilla Frizzola, María Liz Villagra Carrón, Verónica Ortiz, Violeta Deluca, Gerardo Salete de Paula, Vanessa |
| dc.date.accessioned.none.fl_str_mv | 2025-09-19T13:34:44Z |
| dc.date.available.none.fl_str_mv | 2025-09-19T13:34:44Z |
| dc.date.issued.none.fl_str_mv | 2023-04-06 |
| dc.format.extent.es.fl_str_mv | 14 páginas |
| dc.identifier.citation.en.fl_str_mv | Bobadilla, M. L., Villagra, V., Ortiz, V., Deluca, G., & Salete de Paula, V. (2023) High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay. PLoS ONE, 18(4), Article e0283542. https://doi.org/10.1371/journal.pone.0283542 |
| dc.identifier.doi.es.fl_str_mv | 10.1371/journal.pone.0283542 |
| dc.identifier.essn.es.fl_str_mv | 1932-6203 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.1371/journal.pone.0283542 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4654 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Public Library of Science |
| dc.relation.projectCONACYT.es.fl_str_mv | PINV15-200 |
| dc.rights.*.fl_str_mv | Atribución/Reconocimiento 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.es.fl_str_mv | 7. Salud 7.3. Prevención, vigilancia y control de enfermedades transmisibles y no transmisibles |
| dc.subject.ocde.es.fl_str_mv | 3. Ciencias Médicas y de la Salud 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| dc.subject.other.en.fl_str_mv | Coinfection Cross-sectional studies Female Genotype Papillomavirus infections Epidemiological monitoring Prevalence Genotyping techniques Mass vaccination Papillomavirus vaccines Human Papillomavirus Viruses |
| dc.subject.other.es.fl_str_mv | Coinfección Estudios transversales Femenino Genotipo Infecciones por papillomavirus Monitoreo epidemiológico Prevalencia Técnicas de genotipaje Vacunación masiva Vacunas contra papillomavirus Virus del Papiloma Humano |
| dc.title.es.fl_str_mv | High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Correspondencia: bobadillaml@gmail.com. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_761c3353fce50ef1b7e2f5e9fda4bbc2 |
| identifier_str_mv | Bobadilla, M. L., Villagra, V., Ortiz, V., Deluca, G., & Salete de Paula, V. (2023) High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay. PLoS ONE, 18(4), Article e0283542. https://doi.org/10.1371/journal.pone.0283542 10.1371/journal.pone.0283542 1932-6203 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4654 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución/Reconocimiento 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | 16160011726000000-0002-1950-527438756fa7-79a8-400f-8bae-51770d6f40f06002a2484ff-6a66-4f42-bda2-cc94ee6d175e6007bc9e527-3f93-4bcc-83fc-323b518f9514600Ministerio de Salud Pública y Bienestar Social. Laboratorio Central de Salud Pública2025-09-19T13:34:44Z2025-09-19T13:34:44Z2023-04-06Bobadilla, M. L., Villagra, V., Ortiz, V., Deluca, G., & Salete de Paula, V. (2023) High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay. PLoS ONE, 18(4), Article e0283542. https://doi.org/10.1371/journal.pone.0283542https://doi.org/10.1371/journal.pone.0283542http://hdl.handle.net/20.500.14066/465410.1371/journal.pone.02835421932-6203Correspondencia: bobadillaml@gmail.com.Paraguay launched a human papillomavirus (HPV) vaccination program in 2013, so virological surveillance is important for measuring the impact of HPV vaccines. This study aimed to estimate the type-specific HPV frequency in unvaccinated sexually active women aged 18– 25 years in the metropolitan area of Asuncion as a baseline for monitoring the HPV vaccination program. This study included 208 women, attending the Central Laboratory of Public Health between May 2020 and December 2021, were invited for testing through social networks and flyers at local health centers and higher education institutes. All participants who agreed to contribute to the study signed a free, prior, and informed consent form and answered a questionnaire that included basic demographic data and determining factors of HPV infection. Human papillomavirus detection and genotyping were conducted using the CLART HPV2 test (Genomica, Madrid, Spain) that allows the individual identification of 35 genotypes. 54.8% women were positive for any HPV type, with 42.3% positive for high-risk HPV (HR-HPV) types. Several factors were associated with HPV detection including the number of sexual partners, new sexual partners, non-use of condoms, and history of other sexual infections. Moreover, multiple infections were identified in 43.0% of the young women. We detected 29 different viral types present in both single and multiple infections. HPV-58 was the most commonly detected HPV type (14.9%), followed by HPV-16, HPV-51, and HPV-66 (12.3%). We estimated the prevalence of bivalent (16/18), quadrivalent (6/11/ 16/18), and nonavalent (6/11/16/18/31/33/45/52/58) vaccine types to be 8.2%, 13%, and 38%, respectively. These results reinforce the importance of surveillance studies and provide the first data regarding circulating HPV genotypes in the unvaccinated population in Paraguay, thus generating a baseline to compare future changes in the overall and typespecific HPV prevalence after HPV vaccination.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrollo14 páginasengPublic Library of ScienceAtribución/Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2023 Bobadilla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.7. Salud7.3. Prevención, vigilancia y control de enfermedades transmisibles y no transmisiblesCoinfecciónEstudios transversalesFemeninoGenotipoInfecciones por papillomavirusMonitoreo epidemiológicoPrevalenciaTécnicas de genotipajeVacunación masivaVacunas contra papillomavirusVirus del Papiloma HumanoCoinfectionCross-sectional studiesFemaleGenotypePapillomavirus infectionsEpidemiological monitoringPrevalenceGenotyping techniquesMass vaccinationPapillomavirus vaccinesHuman Papillomavirus Viruses3. Ciencias Médicas y de la Salud3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología)High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguayinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4PLoS ONEPINV15-20018Bobadilla Frizzola, María LizVillagra Carrón, VerónicaOrtiz, VioletaDeluca, GerardoSalete de Paula, VanessaORIGINALHigh prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay.pdfHigh prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay.pdfArtículo científicoapplication/pdf964305http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/1/High%20prevalence%20and%20co-infection%20of%20high-risk%20Human%20Papillomavirus%20genotypes%20among%20unvaccinated%20young%20women%20from%20Paraguay.pdfae7cdafcecd0b19764409cc0a9a05c15MD51THUMBNAILHigh prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay.jpgHigh prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay.jpgVista de primera página de artículo científicoimage/jpeg483755http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/4/High%20prevalence%20and%20co-infection%20of%20high-risk%20Human%20Papillomavirus%20genotypes%20among%20unvaccinated%20young%20women%20from%20Paraguay.jpgf6642ec91cd24cd058c338f50db50ef0MD54CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/2/license_rdf0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/3/license.txt858b22fda432bd774e469302988c1974MD53TEXTHigh prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay.pdf.txtHigh prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay.pdf.txtExtracted texttext/plain53888http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4654/5/High%20prevalence%20and%20co-infection%20of%20high-risk%20Human%20Papillomavirus%20genotypes%20among%20unvaccinated%20young%20women%20from%20Paraguay.pdf.txt835017b81cd3db9003cefa16cf7472fbMD5520.500.14066/4654oai:repositorio.conacyt.gov.py:20.500.14066/46542026-02-12 19:30:42.501Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.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 |
| spellingShingle | High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay Bobadilla Frizzola, María Liz 7. Salud 7.3. Prevención, vigilancia y control de enfermedades transmisibles y no transmisibles Coinfección Estudios transversales Femenino Genotipo Infecciones por papillomavirus Monitoreo epidemiológico Prevalencia Técnicas de genotipaje Vacunación masiva Vacunas contra papillomavirus Virus del Papiloma Humano Coinfection Cross-sectional studies Female Genotype Papillomavirus infections Epidemiological monitoring Prevalence Genotyping techniques Mass vaccination Papillomavirus vaccines Human Papillomavirus Viruses 3. Ciencias Médicas y de la Salud 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| status_str | publishedVersion |
| title | High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay |
| title_full | High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay |
| title_fullStr | High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay |
| title_full_unstemmed | High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay |
| title_short | High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay |
| title_sort | High prevalence and co-infection of high-risk Human Papillomavirus genotypes among unvaccinated young women from Paraguay |
| topic | 7. Salud 7.3. Prevención, vigilancia y control de enfermedades transmisibles y no transmisibles Coinfección Estudios transversales Femenino Genotipo Infecciones por papillomavirus Monitoreo epidemiológico Prevalencia Técnicas de genotipaje Vacunación masiva Vacunas contra papillomavirus Virus del Papiloma Humano Coinfection Cross-sectional studies Female Genotype Papillomavirus infections Epidemiological monitoring Prevalence Genotyping techniques Mass vaccination Papillomavirus vaccines Human Papillomavirus Viruses 3. Ciencias Médicas y de la Salud 3.3. Ciencias de la Salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| url | https://doi.org/10.1371/journal.pone.0283542 http://hdl.handle.net/20.500.14066/4654 |