Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population
Corresponding author: Professor Patricia Langjahr, PhD. Facultad de Ciencias Químicas, Universidad Nacional de Asunción. San Lorenzo - Paraguay. Tel: (+595)21585562/3, Int 155. Email: plangjahr@qui.una.py
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| Other Authors: | , , , , , |
| Format: | article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://doi.org/10.3855/jidc.16955 http://hdl.handle.net/20.500.14066/4372 |
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| _version_ | 1870612069760368640 |
|---|---|
| author | Samudio, Angélica |
| author2 | Sotelo Torres, Pablo Hernán González Maldonado, Pamela Alfonso, Laura Valiente Echeverría, Fernando Soto Rifo, Ricardo Langjahr Penayo, Patricia Elena |
| author2_role | author author author author author author |
| author_browse | Alfonso, Laura González Maldonado, Pamela Langjahr Penayo, Patricia Elena Samudio, Angélica Sotelo Torres, Pablo Hernán Soto Rifo, Ricardo Valiente Echeverría, Fernando |
| author_facet | Samudio, Angélica Sotelo Torres, Pablo Hernán González Maldonado, Pamela Alfonso, Laura Valiente Echeverría, Fernando Soto Rifo, Ricardo Langjahr Penayo, Patricia Elena |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/1/Neutralizing%20antibodies%20from%20naturally%20infected%20individuals.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/4/Neutralizing%20antibodies%20from%20naturally%20infected%20individuals.jpg http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/5/Neutralizing%20antibodies%20from%20naturally%20infected%20individuals.pdf.txt |
| dc.contributor.other.es.fl_str_mv | Fundación Facultad de Ciencias Químicas Fundación Centro de Información y Recursos para el Desarrollo |
| dc.creator.none.fl_str_mv | Samudio, Angélica Sotelo Torres, Pablo Hernán González Maldonado, Pamela Alfonso, Laura Valiente Echeverría, Fernando Soto Rifo, Ricardo Langjahr Penayo, Patricia Elena |
| dc.date.accessioned.none.fl_str_mv | 2024-02-26T19:32:10Z |
| dc.date.available.none.fl_str_mv | 2024-02-26T19:32:10Z |
| dc.date.issued.none.fl_str_mv | 2023-10-31 |
| dc.identifier.citation.en.fl_str_mv | Samudio, A., Sotelo, P. H., González Maldonado, P., Alfonso, L., Valiente Echeverría, F., Soto Rifo, R., & Langjahr, P. (2023). Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population. The Journal of Infection in Developing Countries, 17(10), 1407-1412. https://doi.org/10.3855/jidc.16955 |
| dc.identifier.doi.es.fl_str_mv | 10.3855/jidc.16955 |
| dc.identifier.essn.es.fl_str_mv | 1972-2680 |
| dc.identifier.other.none.fl_str_mv | https://doi.org/10.3855/jidc.16955 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4372 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Journal of Infection in Developing Countries |
| dc.relation.projectCONACYT.*.fl_str_mv | PINV20-6 PINV20-388 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.mesh.en.fl_str_mv | Antibodies, viral Antibodies, neutralizing COVID-19 Humans SARS-CoV-2 |
| dc.subject.mesh.es.fl_str_mv | Anticuerpos antivirales Anticuerpos neutralizantes COVID-19 Humanos SARS-CoV-2 |
| dc.subject.other.es.fl_str_mv | Convalescence COVID-19 Neutralizing antibodies SARS-CoV-2 Seroprevalence Variants |
| dc.title.es.fl_str_mv | Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Corresponding author: Professor Patricia Langjahr, PhD. Facultad de Ciencias Químicas, Universidad Nacional de Asunción. San Lorenzo - Paraguay. Tel: (+595)21585562/3, Int 155. Email: plangjahr@qui.una.py |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_8e17b36dda6680452f4cefb718de538b |
| identifier_str_mv | Samudio, A., Sotelo, P. H., González Maldonado, P., Alfonso, L., Valiente Echeverría, F., Soto Rifo, R., & Langjahr, P. (2023). Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population. The Journal of Infection in Developing Countries, 17(10), 1407-1412. https://doi.org/10.3855/jidc.16955 10.3855/jidc.16955 1972-2680 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4372 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | 27a198a8-1e1b-49dc-8644-5bb12305bdf560011006000000-0002-6473-213415523000-3835-4a1e-8abb-4a22f1ef40796009f56b847-b51c-496e-b466-6a12c9b4a63e600088a772a-2b47-4fc8-b917-81dd86c2e67f60033826441-a8f5-4cc5-b596-f899d151c4b1600642600Fundación Facultad de Ciencias QuímicasFundación Centro de Información y Recursos para el Desarrollo2024-02-26T19:32:10Z2024-02-26T19:32:10Z2023-10-31Samudio, A., Sotelo, P. H., González Maldonado, P., Alfonso, L., Valiente Echeverría, F., Soto Rifo, R., & Langjahr, P. (2023). Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population. The Journal of Infection in Developing Countries, 17(10), 1407-1412. https://doi.org/10.3855/jidc.16955https://doi.org/10.3855/jidc.16955http://hdl.handle.net/20.500.14066/437210.3855/jidc.169551972-2680Corresponding author: Professor Patricia Langjahr, PhD. Facultad de Ciencias Químicas, Universidad Nacional de Asunción. San Lorenzo - Paraguay. Tel: (+595)21585562/3, Int 155. Email: plangjahr@qui.una.pyIntroduction: Severe Acute Respiratory Syndrome-Coronavirus-2 Virus (SARS-CoV-2) is responsible for Coronavirus Disease 2019 (COVID-19). A substantial number of SARS-CoV-2 infection cases have been reported during the pandemic, and vaccination coverage in some regions, particularly in developing countries, remains very low. SARS-CoV-2 variants of concern (VOCs) have also emerged as some of the most pressing public health issues. In this scenario, it is crucial to know whether COVID-19 convalescent antibodies have cross-neutralizing action against VOCs to contribute to the analysis of the future progress of the pandemic. Methodology: The plasma of individuals infected with SARS-CoV-2 from June to November 2020 in Paraguay (before the first recorded infections associated with VOCs in the country) was selected. Anti-spike antibodies were determined in plasma samples (n = 626) obtained from this convalescent and unvaccinated group. Using a pseudotyped virus neutralization assay, we then investigated the neutralizing response against D614G variant and Gamma, and Delta VOCs. Results: IgG antibodies against spike were detected in 85.6% of convalescent individuals. Samples from individuals previously infected by a non-VOC showed a 6.6- and 8.1-fold reduction in neutralizing capacity to the Gamma and Delta variants, respectively, when compared to the D614G variant. Conclusions: Our findings show that antibodies generated by non-VOC infection have reduced neutralizing capabilities against Gamma and Delta variants that appeared subsequently and might have implications for immunity strategies.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloengJournal of Infection in Developing CountriesAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2023 Samudio et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Anticuerpos antiviralesAnticuerpos neutralizantesCOVID-19HumanosSARS-CoV-2Antibodies, viralAntibodies, neutralizingCOVID-19HumansSARS-CoV-2ConvalescenceCOVID-19Neutralizing antibodiesSARS-CoV-2SeroprevalenceVariantsNeutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan populationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10The Journal of Infection in Developing Countries14071412PINV20-6PINV20-38817Samudio, AngélicaSotelo Torres, Pablo HernánGonzález Maldonado, PamelaAlfonso, LauraValiente Echeverría, FernandoSoto Rifo, RicardoLangjahr Penayo, Patricia ElenaORIGINALNeutralizing antibodies from naturally infected individuals.pdfNeutralizing antibodies from naturally infected individuals.pdfArtículo científicoapplication/pdf726956http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/1/Neutralizing%20antibodies%20from%20naturally%20infected%20individuals.pdf66853fe0cd047daf3098c882353d9d54MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/2/license_rdf0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/3/license.txt858b22fda432bd774e469302988c1974MD53THUMBNAILNeutralizing antibodies from naturally infected individuals.jpgNeutralizing antibodies from naturally infected individuals.jpgPortadaimage/jpeg1109421http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/4/Neutralizing%20antibodies%20from%20naturally%20infected%20individuals.jpg84ed24011dbaf873cd06db5433da5618MD54TEXTNeutralizing antibodies from naturally infected individuals.pdf.txtNeutralizing antibodies from naturally infected individuals.pdf.txtExtracted texttext/plain26964http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4372/5/Neutralizing%20antibodies%20from%20naturally%20infected%20individuals.pdf.txt3f8d5d7fae8a2010e2d0f8f4c0099c22MD5520.500.14066/4372oai:repositorio.conacyt.gov.py:20.500.14066/43722026-02-12 19:30:35.284Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.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 |
| spellingShingle | Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population Samudio, Angélica Anticuerpos antivirales Anticuerpos neutralizantes COVID-19 Humanos SARS-CoV-2 Antibodies, viral Antibodies, neutralizing COVID-19 Humans SARS-CoV-2 Convalescence COVID-19 Neutralizing antibodies SARS-CoV-2 Seroprevalence Variants |
| status_str | publishedVersion |
| title | Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population |
| title_full | Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population |
| title_fullStr | Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population |
| title_full_unstemmed | Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population |
| title_short | Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population |
| title_sort | Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population |
| topic | Anticuerpos antivirales Anticuerpos neutralizantes COVID-19 Humanos SARS-CoV-2 Antibodies, viral Antibodies, neutralizing COVID-19 Humans SARS-CoV-2 Convalescence COVID-19 Neutralizing antibodies SARS-CoV-2 Seroprevalence Variants |
| url | https://doi.org/10.3855/jidc.16955 http://hdl.handle.net/20.500.14066/4372 |