LanDis : the disease landscape explorer
Corresponding author. Correspondence to Alberto Paccanaro. Email: alberto.paccanaro@rhul.ac.uk.
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| Format: | article |
| Sprache: | Englisch |
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2024
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| Online-Zugang: | https://doi.org/10.1038/s41431-023-01511-9 http://hdl.handle.net/20.500.14066/4734 |
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| _version_ | 1870612070210207744 |
|---|---|
| author | Caniza Vierci, Horacio José |
| author2 | Cáceres Silva, Juan José Torres Bobadilla, Mateo Fernando Paccanaro, Alberto |
| author2_role | author author author |
| author_browse | Caniza Vierci, Horacio José Cáceres Silva, Juan José Paccanaro, Alberto Torres Bobadilla, Mateo Fernando |
| author_facet | Caniza Vierci, Horacio José Cáceres Silva, Juan José Torres Bobadilla, Mateo Fernando Paccanaro, Alberto |
| author_role | author |
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| dc.contributor.other.es.fl_str_mv | Universidad Católica Nuestra Señora de la Asunción Cámara Paraguaya de Exportadores y Comercializadores de Cereales y Oleaginosas Centro de Ingeniería para la Investigación, Desarrollo e Innovación Tecnológica |
| dc.creator.none.fl_str_mv | Caniza Vierci, Horacio José Cáceres Silva, Juan José Torres Bobadilla, Mateo Fernando Paccanaro, Alberto |
| dc.date.accessioned.none.fl_str_mv | 2026-01-06T17:28:15Z |
| dc.date.available.none.fl_str_mv | 2026-01-06T17:28:15Z |
| dc.date.issued.none.fl_str_mv | 2024-01-10 |
| dc.identifier.citation.en.fl_str_mv | Caniza, H., Cáceres, J. J., Torres, M., & Paccanaro, A. (2024). LanDis: the disease landscape explorer. European Journal of Human Genetics, 32, 461-465. https://doi.org/10.1038/s41431-023-01511-9 |
| dc.identifier.doi.es.fl_str_mv | 10.1038/s41431-023-01511-9 |
| dc.identifier.essn.es.fl_str_mv | 1476-5438 |
| dc.identifier.issn.es.fl_str_mv | 1018-4813 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.1038/s41431-023-01511-9 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4734 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Springer Nature |
| dc.relation.projectCONACYT.es.fl_str_mv | 14-INV-088 PINV15-315 PINV20-337 |
| dc.rights.*.fl_str_mv | Atribución/Reconocimiento 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.copyright.es.fl_str_mv | © The Author(s) 2024 |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.es.fl_str_mv | 6. Producción y tecnología industrial 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations 8. Agricultura 8.2. Fertilizantes químicos, biocidas, control biológico de plagas y mecanización de la agricultura |
| dc.subject.ocde.es.fl_str_mv | 4. Ciencias Agrícolas y Veterinarias 4.1. Agricultura, silvicultura, pesca y ciencias afines (agronomía, zootecnia, pesca, silvicultura, horticultura, otras disciplinas afines) |
| dc.subject.other.es.fl_str_mv | Data processing Genetics research Genome informatics |
| dc.title.es.fl_str_mv | LanDis : the disease landscape explorer |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Corresponding author. Correspondence to Alberto Paccanaro. Email: alberto.paccanaro@rhul.ac.uk. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_9ba1e0cfe1ca5f151b166f10a8c46e5a |
| identifier_str_mv | Caniza, H., Cáceres, J. J., Torres, M., & Paccanaro, A. (2024). LanDis: the disease landscape explorer. European Journal of Human Genetics, 32, 461-465. https://doi.org/10.1038/s41431-023-01511-9 1018-4813 10.1038/s41431-023-01511-9 1476-5438 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4734 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución/Reconocimiento 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ © The Author(s) 2024 |
| spelling | 244600228600deae961b-58d4-482b-843a-1d09e278b72d60024e1bdd6-b0df-48fb-a39e-baec166f788d600Universidad Católica Nuestra Señora de la AsunciónCámara Paraguaya de Exportadores y Comercializadores de Cereales y OleaginosasCentro de Ingeniería para la Investigación, Desarrollo e Innovación Tecnológica2026-01-06T17:28:15Z2026-01-06T17:28:15Z2024-01-10Caniza, H., Cáceres, J. J., Torres, M., & Paccanaro, A. (2024). LanDis: the disease landscape explorer. European Journal of Human Genetics, 32, 461-465. https://doi.org/10.1038/s41431-023-01511-91018-4813https://doi.org/10.1038/s41431-023-01511-9http://hdl.handle.net/20.500.14066/473410.1038/s41431-023-01511-91476-5438Corresponding author. Correspondence to Alberto Paccanaro. Email: alberto.paccanaro@rhul.ac.uk.From a network medicine perspective, a disease is the consequence of perturbations on the interactome. These perturbations tend to appear in a specific neighbourhood on the interactome, the disease module, and modules related to phenotypically similar diseases tend to be located in close-by regions. We present LanDis, a freely available web-based interactive tool (https://paccanarolab.org/landis) that allows domain experts, medical doctors and the larger scientific community to graphically navigate the interactome distances between the modules of over 44 million pairs of heritable diseases. The map-like interface provides detailed comparisons between pairs of diseases together with supporting evidence. Every disease in LanDis is linked to relevant entries in OMIM and UniProt, providing a starting point for in-depth analysis and an opportunity for novel insight into the aetiology of diseases as well as differential diagnosis.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloengSpringer NatureAtribución/Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© The Author(s) 20246. Producción y tecnología industrial6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations8. Agricultura8.2. Fertilizantes químicos, biocidas, control biológico de plagas y mecanización de la agriculturaData processingGenetics researchGenome informatics4. Ciencias Agrícolas y Veterinarias4.1. 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| spellingShingle | LanDis : the disease landscape explorer Caniza Vierci, Horacio José 6. Producción y tecnología industrial 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations 8. Agricultura 8.2. Fertilizantes químicos, biocidas, control biológico de plagas y mecanización de la agricultura Data processing Genetics research Genome informatics 4. Ciencias Agrícolas y Veterinarias 4.1. Agricultura, silvicultura, pesca y ciencias afines (agronomía, zootecnia, pesca, silvicultura, horticultura, otras disciplinas afines) |
| status_str | publishedVersion |
| title | LanDis : the disease landscape explorer |
| title_full | LanDis : the disease landscape explorer |
| title_fullStr | LanDis : the disease landscape explorer |
| title_full_unstemmed | LanDis : the disease landscape explorer |
| title_short | LanDis : the disease landscape explorer |
| title_sort | LanDis : the disease landscape explorer |
| topic | 6. Producción y tecnología industrial 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations 8. Agricultura 8.2. Fertilizantes químicos, biocidas, control biológico de plagas y mecanización de la agricultura Data processing Genetics research Genome informatics 4. Ciencias Agrícolas y Veterinarias 4.1. Agricultura, silvicultura, pesca y ciencias afines (agronomía, zootecnia, pesca, silvicultura, horticultura, otras disciplinas afines) |
| url | https://doi.org/10.1038/s41431-023-01511-9 http://hdl.handle.net/20.500.14066/4734 |