Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients
Corresponding author: Isabel Acosta-Colman, Department of Rheumatology, Faculty of Medical Sciences, National University of Asunción, San Lorenzo, Paraguay; email: dr.acostacolman@gmail.com
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| Other Authors: | , , , , , , , |
| Format: | article |
| Language: | English |
| Published: |
2023
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| Online Access: | http://hdl.handle.net/20.500.14066/4307 |
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| _version_ | 1870612070652706816 |
|---|---|
| author | Acosta Colmán de Conrads, María Isabel |
| author2 | Morel Ayala, Zoilo Ramón Pastor Ayala Lugo, Ana Ilda Jolly, Valerie Arévalo de Guillén, Ivalena Langjahr Penayo, Patricia Elena Vázquez, Marcos Martínez de Filártiga, María Teresa Acosta de Hetter, María Eugenia |
| author2_role | author author author author author author author author |
| author_browse | Acosta Colmán de Conrads, María Isabel Acosta de Hetter, María Eugenia Arévalo de Guillén, Ivalena Ayala Lugo, Ana Ilda Jolly, Valerie Langjahr Penayo, Patricia Elena Martínez de Filártiga, María Teresa Morel Ayala, Zoilo Ramón Pastor Vázquez, Marcos |
| author_facet | Acosta Colmán de Conrads, María Isabel Morel Ayala, Zoilo Ramón Pastor Ayala Lugo, Ana Ilda Jolly, Valerie Arévalo de Guillén, Ivalena Langjahr Penayo, Patricia Elena Vázquez, Marcos Martínez de Filártiga, María Teresa Acosta de Hetter, María Eugenia |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/1/Clinical%20features%20and%20genetic%20biomarkers.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/4/Clinical%20features%20and%20genetic%20biomarkers.jpg http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/5/Clinical%20features%20and%20genetic%20biomarkers.pdf.txt |
| dc.contributor.other.es.fl_str_mv | Laboratorio Curie S.R.L |
| dc.creator.none.fl_str_mv | Acosta Colmán de Conrads, María Isabel Morel Ayala, Zoilo Ramón Pastor Ayala Lugo, Ana Ilda Jolly, Valerie Arévalo de Guillén, Ivalena Langjahr Penayo, Patricia Elena Vázquez, Marcos Martínez de Filártiga, María Teresa Acosta de Hetter, María Eugenia |
| dc.date.accessioned.none.fl_str_mv | 2023-10-04T20:27:23Z |
| dc.date.available.none.fl_str_mv | 2023-10-04T20:27:23Z |
| dc.date.issued.none.fl_str_mv | 2023-07-17 |
| dc.identifier.citation.en.fl_str_mv | Acosta-Colman, I., Morel, Z., Ayala Lugo, A., Jolly, V., de Guillén, I., Langjahr, P., Vázquez, M., Martínez de Filártiga, M., & Acosta, M. (2023). Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients. Reumatismo, 75 (2). https://doi.org/10.4081/reumatismo.2023.1541 |
| dc.identifier.doi.es.fl_str_mv | 10.4081/reumatismo.2023.1541 |
| dc.identifier.issn.es.fl_str_mv | 2240-2683 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4307 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | PAGEPress |
| dc.relation.projectCONACYT.es.fl_str_mv | 14-INV-039 |
| dc.rights.*.fl_str_mv | Atribución-NoComercial 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.copyright.es.fl_str_mv | © 2023 the Author(s) |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.subject.classification.es.fl_str_mv | 7. Salud |
| dc.subject.other.es.fl_str_mv | Biomarkers Paraguayan Phenotypes Systemic lupus erythematosus |
| dc.title.es.fl_str_mv | Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Corresponding author: Isabel Acosta-Colman, Department of Rheumatology, Faculty of Medical Sciences, National University of Asunción, San Lorenzo, Paraguay; email: dr.acostacolman@gmail.com |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_a5eeef268e8fa96482961b53ff4484a8 |
| identifier_str_mv | Acosta-Colman, I., Morel, Z., Ayala Lugo, A., Jolly, V., de Guillén, I., Langjahr, P., Vázquez, M., Martínez de Filártiga, M., & Acosta, M. (2023). Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients. Reumatismo, 75 (2). https://doi.org/10.4081/reumatismo.2023.1541 2240-2683 10.4081/reumatismo.2023.1541 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4307 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ © 2023 the Author(s) |
| spelling | 11600785600114600626600776006426008679d8af-773d-4f10-992a-45e1473cdf43600722600146000000-0003-0801-4397Laboratorio Curie S.R.L2023-10-04T20:27:23Z2023-10-04T20:27:23Z2023-07-17Acosta-Colman, I., Morel, Z., Ayala Lugo, A., Jolly, V., de Guillén, I., Langjahr, P., Vázquez, M., Martínez de Filártiga, M., & Acosta, M. (2023). Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients. Reumatismo, 75 (2). https://doi.org/10.4081/reumatismo.2023.15412240-2683http://hdl.handle.net/20.500.14066/430710.4081/reumatismo.2023.1541Corresponding author: Isabel Acosta-Colman, Department of Rheumatology, Faculty of Medical Sciences, National University of Asunción, San Lorenzo, Paraguay; email: dr.acostacolman@gmail.comSystemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a heterogeneous clinical picture that makes the diagnosis and follow-up of these patients difficult. This study aimed to identify correlations between clinical, immunological, and genetic biomarkers and clinical manifestations in SLE. A retrospective study of data from medical records and immunological and genetic studies of SLE patients in Paraguay was carried out. A descriptive analysis was performed based on the type of variable. Human leukocyte antigen (HLA) allele frequencies (DPA1, DPB1, DQA1, DQB1, and DRB1) were calculated, and univariate logistic regression analyses were performed between each of the explanatory variables and the presence or absence of each phenotype. Odds ratios, 95% confidence intervals, and p values were recorded. Associations with p<0.05 were considered statistically significant. 104 SLE patients were included: 86% were female, with a mean age of 32.80±10.36 years. An association was identified between anti-double stranded DNA (antidsDNA) and the presence of the renal phenotype and between anti-dsDNA and the absence of the joint and hematological phenotypes. Immunoglobulin M isotype rheumatoid factor was associated with the absence of a renal phenotype. HLA-DQB1*02:02 and HLA-DRB1*07:01 were associated with the cutaneous phenotype. An association was identified between age at disease onset over 30 years and the presence of the joint phenotype. No other associations were identified. Potential clinical, immunological, and genetic biomarkers of phenotypes have been identified in SLE Paraguayan patients.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloengPAGEPressAtribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccess© 2023 the Author(s)7. SaludBiomarkersParaguayanPhenotypesSystemic lupus erythematosusClinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patientsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2Reumatismo657514-INV-03975Acosta Colmán de Conrads, María IsabelMorel Ayala, Zoilo Ramón PastorAyala Lugo, Ana IldaJolly, ValerieArévalo de Guillén, IvalenaLangjahr Penayo, Patricia ElenaVázquez, MarcosMartínez de Filártiga, María TeresaAcosta de Hetter, María EugeniaORIGINALClinical features and genetic biomarkers.pdfClinical features and genetic biomarkers.pdfArtículo científicoapplication/pdf3999414http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/1/Clinical%20features%20and%20genetic%20biomarkers.pdf8c8cdff702168a8fc27e8154afa90231MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/2/license_rdf24013099e9e6abb1575dc6ce0855efd5MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/3/license.txt858b22fda432bd774e469302988c1974MD53THUMBNAILClinical features and genetic biomarkers.jpgClinical features and genetic biomarkers.jpgPortadaimage/jpeg804005http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/4/Clinical%20features%20and%20genetic%20biomarkers.jpg6c934bb70137c72c9623014b4627405eMD54TEXTClinical features and genetic biomarkers.pdf.txtClinical features and genetic biomarkers.pdf.txtExtracted texttext/plain40241http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4307/5/Clinical%20features%20and%20genetic%20biomarkers.pdf.txt07621d36e850ae52f324bbe73a350699MD5520.500.14066/4307oai:repositorio.conacyt.gov.py:20.500.14066/43072026-02-12 19:30:34.415Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.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 |
| spellingShingle | Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients Acosta Colmán de Conrads, María Isabel 7. Salud Biomarkers Paraguayan Phenotypes Systemic lupus erythematosus |
| status_str | publishedVersion |
| title | Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients |
| title_full | Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients |
| title_fullStr | Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients |
| title_full_unstemmed | Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients |
| title_short | Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients |
| title_sort | Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients |
| topic | 7. Salud Biomarkers Paraguayan Phenotypes Systemic lupus erythematosus |
| url | http://hdl.handle.net/20.500.14066/4307 |