Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking
Correspondence: nverabilbao@gmail.com (N.V.d.B.); alain.fournet@orange.fr (A.F.)
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| Format: | article |
| Language: | English |
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2025
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| Online Access: | https://doi.org/10.3390/plants14060954 http://hdl.handle.net/20.500.14066/4552 |
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| _version_ | 1870612072481423360 |
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| author | Vera de Bilbao, Ninfa |
| author2 | Giebelhaus, Ryland T. Dias, Ryan P. Ferreira de Paredes, María Elena Martínez, Miguel Velasco Carneros, Lorea Nam, Seo Lin de la Mata, Aidee Paulina Maréchal, Jean-Didier Adou, Ahissan Innocent Yaluff Miranda, Gloria Cristina Serna, María Elva Sylvestre, Muriel Torres de Ortiz, Agueda Susana Schinini Vega, Alicia Petrona Galeano, Ricardo Fournet, Alain Harynuk, James J. Cebrian Torrejon, Gerardo |
| author2_role | author author author author author author author author author author author author author author author author author author |
| author_browse | Adou, Ahissan Innocent Cebrian Torrejon, Gerardo Dias, Ryan P. Ferreira de Paredes, María Elena Fournet, Alain Galeano, Ricardo Giebelhaus, Ryland T. Harynuk, James J. Martínez, Miguel Maréchal, Jean-Didier Nam, Seo Lin Schinini Vega, Alicia Petrona Serna, María Elva Sylvestre, Muriel Torres de Ortiz, Agueda Susana Velasco Carneros, Lorea Vera de Bilbao, Ninfa Yaluff Miranda, Gloria Cristina de la Mata, Aidee Paulina |
| author_facet | Vera de Bilbao, Ninfa Giebelhaus, Ryland T. Dias, Ryan P. Ferreira de Paredes, María Elena Martínez, Miguel Velasco Carneros, Lorea Nam, Seo Lin de la Mata, Aidee Paulina Maréchal, Jean-Didier Adou, Ahissan Innocent Yaluff Miranda, Gloria Cristina Serna, María Elva Sylvestre, Muriel Torres de Ortiz, Agueda Susana Schinini Vega, Alicia Petrona Galeano, Ricardo Fournet, Alain Harynuk, James J. Cebrian Torrejon, Gerardo |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/1/Exploring%20the%20anti-Chagas%20activity%20of%20Zanthoxylum%20chiloperone%e2%80%99s%20seedlings%20through%20metabolomics%20and%20protein-ligand%20docking.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/4/Material%20suplementario.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/5/Exploring%20the%20anti-Chagas%20activity%20of%20Zanthoxylum%20chiloperone%e2%80%99s.jpg http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/6/Exploring%20the%20anti-Chagas%20activity%20of%20Zanthoxylum%20chiloperone%e2%80%99s%20seedlings%20through%20metabolomics%20and%20protein-ligand%20docking.pdf.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/7/Material%20suplementario.pdf.txt |
| dc.contributor.other.es.fl_str_mv | Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud |
| dc.creator.none.fl_str_mv | Vera de Bilbao, Ninfa Giebelhaus, Ryland T. Dias, Ryan P. Ferreira de Paredes, María Elena Martínez, Miguel Velasco Carneros, Lorea Nam, Seo Lin de la Mata, Aidee Paulina Maréchal, Jean-Didier Adou, Ahissan Innocent Yaluff Miranda, Gloria Cristina Serna, María Elva Sylvestre, Muriel Torres de Ortiz, Agueda Susana Schinini Vega, Alicia Petrona Galeano, Ricardo Fournet, Alain Harynuk, James J. Cebrian Torrejon, Gerardo |
| dc.date.accessioned.none.fl_str_mv | 2025-04-02T17:31:30Z |
| dc.date.available.none.fl_str_mv | 2025-04-02T17:31:30Z |
| dc.date.issued.none.fl_str_mv | 2025-03-18 |
| dc.identifier.citation.en.fl_str_mv | de Bilbao, N. V., Giebelhaus, R. T., Dias, R. P., Ferreira, M. E., Martínez, M., Velasco Carneros, L., Nam, S. L., de la Mata, A. P., Maréchal, J. D., Adou, A. I., Yaluff, G., Serna, E., Sylvestre, M., Torres, S., Schinini, A., Galeano, R., Fournet, A., Harynuk, J. J., & Cebrián Torrejón, G. (2025). Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking. Plants, 14(6), Artículo 954. https://doi.org/10.3390/plants14060954 |
| dc.identifier.doi.es.fl_str_mv | 10.3390/plants14060954 |
| dc.identifier.essn.es.fl_str_mv | 2223-7747 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.3390/plants14060954 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4552 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Multidisciplinary Digital Publishing Institute |
| dc.relation.projectCONACYT.es.fl_str_mv | 14-INV-151 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.en.fl_str_mv | 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations |
| dc.subject.classification.es.fl_str_mv | 6. Producción y tecnología industrial |
| dc.subject.other.es.fl_str_mv | Canthin-6-ones Chagas disease Medicinal plants Natural products Plant metabolomics Rutaceae |
| dc.title.es.fl_str_mv | Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Correspondence: nverabilbao@gmail.com (N.V.d.B.); alain.fournet@orange.fr (A.F.) |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_da2fa066404b8373e084aa5efb47486a |
| identifier_str_mv | de Bilbao, N. V., Giebelhaus, R. T., Dias, R. P., Ferreira, M. E., Martínez, M., Velasco Carneros, L., Nam, S. L., de la Mata, A. P., Maréchal, J. D., Adou, A. I., Yaluff, G., Serna, E., Sylvestre, M., Torres, S., Schinini, A., Galeano, R., Fournet, A., Harynuk, J. J., & Cebrián Torrejón, G. (2025). Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking. Plants, 14(6), Artículo 954. https://doi.org/10.3390/plants14060954 10.3390/plants14060954 2223-7747 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4552 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | a5f42a64-d842-4f2f-839a-f0860194e72d6003bbc804d-1699-428d-a70b-18653bf6a999600323fdbde-718f-42f2-85c0-d35fd6bcc3bf6004296007146008f91841d-3c31-42e2-9f26-2477611979b9600e751cd2b-8803-4aa1-ab5a-8488e248b496600c650b955-5330-4b84-90da-442485acecb2600f053e370-9b44-47e1-8f76-b22f1410a3776003f999534-b512-4847-ac36-c67c7dce0a0660012016000000-0002-7568-47561075600689d00d1-9ec3-49c2-b818-2f04e0d01a2060011206000000-0001-8587-458010636004f7e99d3-09d0-4213-9f4b-f236840661dc600d1d5a872-15eb-4364-ab9b-67360f3b74ca6004fde8c9c-d541-4ee0-bb88-60b59f906892600d180b3e7-5c80-430e-97b8-2d23c70cd5ca600Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud2025-04-02T17:31:30Z2025-04-02T17:31:30Z2025-03-18de Bilbao, N. V., Giebelhaus, R. T., Dias, R. P., Ferreira, M. E., Martínez, M., Velasco Carneros, L., Nam, S. L., de la Mata, A. P., Maréchal, J. D., Adou, A. I., Yaluff, G., Serna, E., Sylvestre, M., Torres, S., Schinini, A., Galeano, R., Fournet, A., Harynuk, J. J., & Cebrián Torrejón, G. (2025). Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking. Plants, 14(6), Artículo 954. https://doi.org/10.3390/plants14060954https://doi.org/10.3390/plants14060954http://hdl.handle.net/20.500.14066/455210.3390/plants140609542223-7747Correspondence: nverabilbao@gmail.com (N.V.d.B.); alain.fournet@orange.fr (A.F.)This article belongs to the Section Phytochemistry.This publication reports the controlled cultivation of Zanthoxylum chiloperone var. angustifolium Engl. (Rutaceae) in several growth substrates under controlled greenhouse conditions. This plant is well-known for its anti-Chagas (trypanocidal) activity, related to the presence of several β-carboline alkaloids. The metabolomic study of Z. chiloperone seedlings over two years of growth (2018–2020) was performed using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS). The canthin-6-one alkaloids, canthin-6-one and 5-methoxy-canthin-6-one, were putatively identified in Z. chiloperone extracts. Finally, in vitro and in silico studies of trypanocidal activity were performed, suggesting that canthin-6-one alkaloids could interact with the main pharmacological targets against Trypanosoma cruzi, cruzain protease, dihydroorotate dehydrogenase, lanosterol 14-alpha-demethylase, farnesyl diphosphate, and squalene synthases.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloengMultidisciplinary Digital Publishing InstituteAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations6. Producción y tecnología industrialCanthin-6-onesChagas diseaseMedicinal plantsNatural productsPlant metabolomicsRutaceaeExploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand dockinginfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6Plants14-INV-15114Vera de Bilbao, NinfaGiebelhaus, Ryland T.Dias, Ryan P.Ferreira de Paredes, María ElenaMartínez, MiguelVelasco Carneros, LoreaNam, Seo Linde la Mata, Aidee PaulinaMaréchal, Jean-DidierAdou, Ahissan InnocentYaluff Miranda, Gloria CristinaSerna, María ElvaSylvestre, MurielTorres de Ortiz, Agueda SusanaSchinini Vega, Alicia PetronaGaleano, RicardoFournet, AlainHarynuk, James J.Cebrian Torrejon, GerardoORIGINALExploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking.pdfExploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking.pdfArtículo científicoapplication/pdf1076868http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/1/Exploring%20the%20anti-Chagas%20activity%20of%20Zanthoxylum%20chiloperone%e2%80%99s%20seedlings%20through%20metabolomics%20and%20protein-ligand%20docking.pdfea4d77123c711e19e2fef8994dd1185bMD51Material suplementario.pdfMaterial suplementario.pdfMaterial suplementarioapplication/pdf597410http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4552/4/Material%20suplementario.pdf37132277c7f6e8dbbbeb7c3001b15ee9MD54CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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| spellingShingle | Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking Vera de Bilbao, Ninfa 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations 6. Producción y tecnología industrial Canthin-6-ones Chagas disease Medicinal plants Natural products Plant metabolomics Rutaceae |
| status_str | publishedVersion |
| title | Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking |
| title_full | Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking |
| title_fullStr | Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking |
| title_full_unstemmed | Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking |
| title_short | Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking |
| title_sort | Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking |
| topic | 6.16. Manufacture of basic pharmaceutical products and pharmaceutical preparations 6. Producción y tecnología industrial Canthin-6-ones Chagas disease Medicinal plants Natural products Plant metabolomics Rutaceae |
| url | https://doi.org/10.3390/plants14060954 http://hdl.handle.net/20.500.14066/4552 |