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An Exploratory Analysis on Drug Target Locality

In this paper we perform an exploratory analysis of the genotypic and genotypic relation between drugs and heritable diseases. Since drugs and diseases are a priori incomparable sets, we propose a drug-disease category mapping, to define an intended objective of drug design. We establish metrics suc...

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Autor principal: Cáceres Silva, Juan José (author)
Outros Autores: Burgos Edwards, Alberto Javier (author)
Formato: article
Idioma:inglês
Publicado em: 2017
Assuntos:
6. Producción y tecnología industrial
DRUG TARGETS
PROTEIN-PROTEIN INTERACTION NETWORK
FARMACOLOGIA
Acesso em linha:http://hdl.handle.net/20.500.14066/2998
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author Cáceres Silva, Juan José
author2 Burgos Edwards, Alberto Javier
author2_role author
author_browse Burgos Edwards, Alberto Javier
Cáceres Silva, Juan José
author_facet Cáceres Silva, Juan José
Burgos Edwards, Alberto Javier
author_role author
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858b22fda432bd774e469302988c1974
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bitstream.url.fl_str_mv http://repositorio.conacyt.gov.py/bitstream/20.500.14066/2998/1/14-inv-088art11.pdf
http://repositorio.conacyt.gov.py/bitstream/20.500.14066/2998/2/license.txt
http://repositorio.conacyt.gov.py/bitstream/20.500.14066/2998/3/14-inv-088art11.pdf.txt
dc.contributor.other.es.fl_str_mv Universidad Católica "Nuestra Señora de la Asunción" (PY)
University of London (UK)
dc.creator.none.fl_str_mv Cáceres Silva, Juan José
Burgos Edwards, Alberto Javier
dc.date.accessioned.none.fl_str_mv 2022-04-21T02:23:58Z
dc.date.available.none.fl_str_mv 2022-04-21T02:23:58Z
dc.date.issued.none.fl_str_mv 2017
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.14066/2998
dc.language.iso.es.fl_str_mv eng
dc.relation.projectCONACYT.es.fl_str_mv 14-INV-088
dc.rights.accessRights.es.fl_str_mv info:eu-repo/semantics/openAccess
dc.subject.classification.es.fl_str_mv 6. Producción y tecnología industrial
dc.subject.ocde.es.fl_str_mv FARMACOLOGIA
dc.subject.other.es.fl_str_mv DRUG TARGETS
PROTEIN-PROTEIN INTERACTION NETWORK
dc.title.es.fl_str_mv An Exploratory Analysis on Drug Target Locality
dc.type.es.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
description In this paper we perform an exploratory analysis of the genotypic and genotypic relation between drugs and heritable diseases. Since drugs and diseases are a priori incomparable sets, we propose a drug-disease category mapping, to define an intended objective of drug design. We establish metrics such as the locality and functional similarity of drug targets, to quantify their specificity and possible side effects. The locality of drug targets can be used to analyse the physical mechanism of action drugs use to treat diseases. On the other hand, functional similarity of drug targets reveals functions that can be exploited for drug repursosing.
eu_rights_str_mv openAccess
format article
id CONACYT_de2243f2e4a667c29940aec98052993f
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network_acronym_str CONACYT
network_name_str Repositorio Institucional CONACYT
oai_identifier_str oai:repositorio.conacyt.gov.py:20.500.14066/2998
publishDate 2017
publishDateSort 2017
repository.mail.fl_str_mv repositorio.institucional@conacyt.gov.py
repository.name.fl_str_mv Repositorio Institucional CONACYT
repository_id_str
spelling 228600851600Universidad Católica "Nuestra Señora de la Asunción" (PY)University of London (UK)2022-04-21T02:23:58Z2022-04-21T02:23:58Z2017http://hdl.handle.net/20.500.14066/2998In this paper we perform an exploratory analysis of the genotypic and genotypic relation between drugs and heritable diseases. Since drugs and diseases are a priori incomparable sets, we propose a drug-disease category mapping, to define an intended objective of drug design. We establish metrics such as the locality and functional similarity of drug targets, to quantify their specificity and possible side effects. The locality of drug targets can be used to analyse the physical mechanism of action drugs use to treat diseases. On the other hand, functional similarity of drug targets reveals functions that can be exploited for drug repursosing.Consejo Nacional de Ciencia y TecnologíaPROCIENCIAeng6. Producción y tecnología industrialDRUG TARGETSPROTEIN-PROTEIN INTERACTION NETWORKFARMACOLOGIAAn Exploratory Analysis on Drug Target Localityinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14-INV-088info:eu-repo/semantics/openAccessCáceres Silva, Juan JoséBurgos Edwards, Alberto JavierORIGINAL14-inv-088art11.pdf14-inv-088art11.pdfapplication/pdf1015930http://repositorio.conacyt.gov.py/bitstream/20.500.14066/2998/1/14-inv-088art11.pdf906e2486130b6e654e5c44cf01817c0fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/2998/2/license.txt858b22fda432bd774e469302988c1974MD52TEXT14-inv-088art11.pdf.txt14-inv-088art11.pdf.txtExtracted texttext/plain34272http://repositorio.conacyt.gov.py/bitstream/20.500.14066/2998/3/14-inv-088art11.pdf.txtbce36d81e82bf120de487bbcb9c921b5MD5320.500.14066/2998oai:repositorio.conacyt.gov.py:20.500.14066/29982026-02-12 19:30:23.132Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.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
spellingShingle An Exploratory Analysis on Drug Target Locality
Cáceres Silva, Juan José
6. Producción y tecnología industrial
DRUG TARGETS
PROTEIN-PROTEIN INTERACTION NETWORK
FARMACOLOGIA
status_str publishedVersion
title An Exploratory Analysis on Drug Target Locality
title_full An Exploratory Analysis on Drug Target Locality
title_fullStr An Exploratory Analysis on Drug Target Locality
title_full_unstemmed An Exploratory Analysis on Drug Target Locality
title_short An Exploratory Analysis on Drug Target Locality
title_sort An Exploratory Analysis on Drug Target Locality
topic 6. Producción y tecnología industrial
DRUG TARGETS
PROTEIN-PROTEIN INTERACTION NETWORK
FARMACOLOGIA
url http://hdl.handle.net/20.500.14066/2998

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