Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting
Autor de correspondencia: vhaquino@iics.una.py
I tiakina i:
| Kaituhi matua: | |
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| Ētahi atu kaituhi: | , , |
| Hōputu: | article |
| Reo: | Ingarihi |
| I whakaputaina: |
2023
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| Ngā marau: | |
| Urunga tuihono: | https://doi.org/10.1371/journal.pone.0292314 http://hdl.handle.net/20.500.14066/4366 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1870885391952773120 |
|---|---|
| author | Mesquita Ramírez, Mirta |
| author2 | Zárate, Mirian Noemí Rodríguez, Leonidas Adelaida Aquino Quintana, Víctor Hugo |
| author2_role | author author author |
| author_browse | Aquino Quintana, Víctor Hugo Mesquita Ramírez, Mirta Rodríguez, Leonidas Adelaida Zárate, Mirian Noemí |
| author_facet | Mesquita Ramírez, Mirta Zárate, Mirian Noemí Rodríguez, Leonidas Adelaida Aquino Quintana, Víctor Hugo |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/1/Performance%20evaluation%20of%20Biofire%20Film%20Array%20Respiratory%20Panel%202.1%20for%20SARS-CoV-2.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/6/Proyecto%20COVID-19.xlsx http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/4/Performance%20evaluation%20of%20Biofire%20Film%20Array.pdf.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/7/Proyecto%20COVID-19.xlsx.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/8/Performance%20evaluation%20of%20Biofire%20Film%20Array%20Respiratory%20Panel%202.1%20for%20SARS-CoV-2.pdf.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/5/Performance%20evaluation%20of%20Biofire%20Film%20Array.jpg |
| dc.contributor.other.es.fl_str_mv | Salud y Nutrición - Paraguay SRL |
| dc.creator.none.fl_str_mv | Mesquita Ramírez, Mirta Zárate, Mirian Noemí Rodríguez, Leonidas Adelaida Aquino Quintana, Víctor Hugo |
| dc.date.accessioned.none.fl_str_mv | 2024-01-30T00:42:55Z |
| dc.date.available.none.fl_str_mv | 2024-01-30T00:42:55Z |
| dc.date.issued.none.fl_str_mv | 2023-10-05 |
| dc.identifier.citation.en.fl_str_mv | Mesquita Ramírez, M., Zarate, M. N., Rodríguez, L. A., & Aquino, V. H. (2023). Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting. PloS one, 18(10), Artículo e0292314. https://doi.org/10.1371/journal.pone.0292314 |
| dc.identifier.doi.es.fl_str_mv | 10.1371/journal.pone.0292314 |
| dc.identifier.essn.es.fl_str_mv | 1932-6203 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.1371/journal.pone.0292314 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4366 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Public Library of Science |
| dc.relation.projectCONACYT.es.fl_str_mv | PINV20-287 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.other.es.fl_str_mv | COVID-19/diagnóstico Estudios prospectivos Estudios transversales Hospitales pediátricos Niño Preescolar SARS-CoV-2/genética Sensibilidad y especificidad COVID-19/diagnosis Prospective studies Cross-sectional studies Hospitals, Pediatric Child Child, Preschool SARS-CoV-2/genetics Sensitivity and specificity |
| dc.title.es.fl_str_mv | Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Autor de correspondencia: vhaquino@iics.una.py |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_e8618d79760dc19bd5051caf7f5dd14f |
| identifier_str_mv | Mesquita Ramírez, M., Zarate, M. N., Rodríguez, L. A., & Aquino, V. H. (2023). Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting. PloS one, 18(10), Artículo e0292314. https://doi.org/10.1371/journal.pone.0292314 10.1371/journal.pone.0292314 1932-6203 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4366 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| spelling | f4cf5d89-b3ec-4271-b479-c3a809ae3c896001211600e8fc2600-8490-4890-88e5-283fc61c28d760069600Salud y Nutrición - Paraguay SRL2024-01-30T00:42:55Z2024-01-30T00:42:55Z2023-10-05Mesquita Ramírez, M., Zarate, M. N., Rodríguez, L. A., & Aquino, V. H. (2023). Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting. PloS one, 18(10), Artículo e0292314. https://doi.org/10.1371/journal.pone.0292314https://doi.org/10.1371/journal.pone.0292314http://hdl.handle.net/20.500.14066/436610.1371/journal.pone.02923141932-6203Autor de correspondencia: vhaquino@iics.una.pyThe highly contagious nature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), requires rapid diagnostic tests to prevent the virus from spreading within hospitals and communities. Reverse transcription followed by the polymerase chain reaction (RT-PCR) test is the gold standard for detecting SARS-CoV-2 infections but is time-consuming, labor-intensive, and restricted to centralized laboratories. There is a growing need to develop and implement point-of-care and rapid tests for SARS-CoV-2 detection to address these limitations. We aimed to evaluate the performance of BioFire Film Array Respiratory Panel 2.1 (BioFire FA-RP2.1) for SARS-CoV-2 detection in a pediatric hospital setting. The BioFire FA-RP2.1 test provides rapid results and can identify several viral and bacterial infections in a single test. This prospective, cross-sectional, diagnostic accuracy study enrolled participants ranging from 0 to 18 years of age, seeking medical consultation for any reason, who had been in contact with individuals confirmed to have COVID-19 or managed at the hospital for medical or surgical reasons. We employed a systematic sampling technique to ensure a representative sample. The study included 339 participants with a median age of 5 years. The BioFire FA-RP2.1 test detected SARS-CoV-2 in 18.6% of cases, while the reference RT-PCR test in 14% of cases. The BioFire FA-RP2.1 sensitivity and specificity for SARS CoV-2 detection were 98% and 94%, respectively. The positive probability coefficient (LR+) was 18. The agreement between the two tests was 0.80. In addition, the BioFire FA-RP2.1 test detected coinfection with two viruses in 7,6% of cases. The BioFire FA-RP2.1 is a reliable solution to meet pediatric healthcare needs and improve prognosis in the post-pandemic era thanks to its friendly interface and rapid testing process.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloengPublic Library of ScienceAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2023 Ramirez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.COVID-19/diagnósticoEstudios prospectivosEstudios transversalesHospitales pediátricosNiñoPreescolarSARS-CoV-2/genéticaSensibilidad y especificidadCOVID-19/diagnosisProspective studiesCross-sectional studiesHospitals, PediatricChildChild, PreschoolSARS-CoV-2/geneticsSensitivity and specificityPerformance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital settinginfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10PLOS ONEPINV20-28718Mesquita Ramírez, MirtaZárate, Mirian NoemíRodríguez, Leonidas AdelaidaAquino Quintana, Víctor HugoORIGINALPerformance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2.pdfPerformance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2.pdfArtículo científicoapplication/pdf538910http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4366/1/Performance%20evaluation%20of%20Biofire%20Film%20Array%20Respiratory%20Panel%202.1%20for%20SARS-CoV-2.pdfcdc4c1bf004d2108ff9ea44c83ab9fdcMD51Proyecto COVID-19.xlsxProyecto COVID-19.xlsxAnexo I. 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| spellingShingle | Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting Mesquita Ramírez, Mirta COVID-19/diagnóstico Estudios prospectivos Estudios transversales Hospitales pediátricos Niño Preescolar SARS-CoV-2/genética Sensibilidad y especificidad COVID-19/diagnosis Prospective studies Cross-sectional studies Hospitals, Pediatric Child Child, Preschool SARS-CoV-2/genetics Sensitivity and specificity |
| status_str | publishedVersion |
| title | Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting |
| title_full | Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting |
| title_fullStr | Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting |
| title_full_unstemmed | Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting |
| title_short | Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting |
| title_sort | Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting |
| topic | COVID-19/diagnóstico Estudios prospectivos Estudios transversales Hospitales pediátricos Niño Preescolar SARS-CoV-2/genética Sensibilidad y especificidad COVID-19/diagnosis Prospective studies Cross-sectional studies Hospitals, Pediatric Child Child, Preschool SARS-CoV-2/genetics Sensitivity and specificity |
| url | https://doi.org/10.1371/journal.pone.0292314 http://hdl.handle.net/20.500.14066/4366 |