Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue
Corresponding author: fati.cardozo@hotmail.com (FC); jjwaggo@emory.edu (JJW)
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| Altri autori: | , , , , , , , , , , , , , |
| Natura: | article |
| Lingua: | inglese |
| Pubblicazione: |
2023
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| Accesso online: | http://hdl.handle.net/20.500.14066/4318 |
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| _version_ | 1870612073471279104 |
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| author | Bernal, Cynthia |
| author2 | Ping, Sara Rojas Segovia, Alejandra María Caballero, Oliver Stittleburg, Victoria Arévalo de Guillén, Yvalena Langjahr Penayo, Patricia Elena Pinsky, Benjamin A. Von-Horoch, Marta Luraschi, Patricia Cabral, Sandra Sánchez, María Cecilia Torres, Aurelia Cardozo, Fátima Waggoner, Jesse J. |
| author2_role | author author author author author author author author author author author author author author |
| author_browse | Arévalo de Guillén, Yvalena Bernal, Cynthia Caballero, Oliver Cabral, Sandra Cardozo, Fátima Langjahr Penayo, Patricia Elena Luraschi, Patricia Ping, Sara Pinsky, Benjamin A. Rojas Segovia, Alejandra María Stittleburg, Victoria Sánchez, María Cecilia Torres, Aurelia Von-Horoch, Marta Waggoner, Jesse J. |
| author_facet | Bernal, Cynthia Ping, Sara Rojas Segovia, Alejandra María Caballero, Oliver Stittleburg, Victoria Arévalo de Guillén, Yvalena Langjahr Penayo, Patricia Elena Pinsky, Benjamin A. Von-Horoch, Marta Luraschi, Patricia Cabral, Sandra Sánchez, María Cecilia Torres, Aurelia Cardozo, Fátima Waggoner, Jesse J. |
| author_role | author |
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| dc.contributor.other.es.fl_str_mv | Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud |
| dc.creator.none.fl_str_mv | Bernal, Cynthia Ping, Sara Rojas Segovia, Alejandra María Caballero, Oliver Stittleburg, Victoria Arévalo de Guillén, Yvalena Langjahr Penayo, Patricia Elena Pinsky, Benjamin A. Von-Horoch, Marta Luraschi, Patricia Cabral, Sandra Sánchez, María Cecilia Torres, Aurelia Cardozo, Fátima Waggoner, Jesse J. |
| dc.date.accessioned.none.fl_str_mv | 2023-11-13T18:37:55Z |
| dc.date.available.none.fl_str_mv | 2023-11-13T18:37:55Z |
| dc.date.issued.none.fl_str_mv | 2023-02-27 |
| dc.format.extent.es.fl_str_mv | 18 páginas |
| dc.identifier.citation.en.fl_str_mv | Bernal C, Ping S, Rojas A, Caballero O, Stittleburg V, de Guillén Y, et al. (2023) Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue. PLoS Negl Trop Dis 17(2): e0010750. https://doi.org/10.1371/journal.pntd.0010750 |
| dc.identifier.doi.es.fl_str_mv | 10.1371/journal.pntd.0010750 |
| dc.identifier.essn.es.fl_str_mv | 1935-2735 |
| dc.identifier.issn.es.fl_str_mv | 1935-2727 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4318 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Public Library of Science |
| dc.relation.projectCONACYT.es.fl_str_mv | PINV18-1295 POSG17-59 |
| dc.rights.*.fl_str_mv | Atribución 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.copyright.es.fl_str_mv | © 2023 Bernal et al. |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.classification.es.fl_str_mv | 7. Salud |
| dc.subject.ocde.es.fl_str_mv | 3.3. Ciencias de la salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| dc.subject.other.es.fl_str_mv | Aedes Arbovirus Biomarcadores Dengue Dengue Grave Diagnóstico Aedes Arboviruses Biomarkers Dengue Severe Dengue Diagnosis |
| dc.title.es.fl_str_mv | Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Corresponding author: fati.cardozo@hotmail.com (FC); jjwaggo@emory.edu (JJW) |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_f30cf952a5c7afa413e93a6ee2974f60 |
| identifier_str_mv | Bernal C, Ping S, Rojas A, Caballero O, Stittleburg V, de Guillén Y, et al. (2023) Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue. PLoS Negl Trop Dis 17(2): e0010750. https://doi.org/10.1371/journal.pntd.0010750 1935-2727 10.1371/journal.pntd.0010750 1935-2735 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4318 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ © 2023 Bernal et al. |
| spelling | 142c16ce-dd78-4237-b975-aaa64a424ff9600615deef7-0b5d-4074-bcf8-4dfb7998687e60010026004c48e764-7a69-4502-a617-70faa13d797e600688adc46-8045-48c4-9cb4-e4f379cb8e786009bf1082e-0b69-4c45-988c-6633da9d1b73600642600bb370a93-63ed-4720-a616-649a6874ed2b60074db3d25-d930-4095-b5c0-65bf3c2669866006ff9408f-2e2a-481b-aedf-d64e8df85e526008ca04f0c-0c0d-4759-9182-45e846fdc794600ca0d95cf-1f73-445f-9b2f-dfccfb24dd92600de66270e-a87c-4a57-af2e-d51741dc51e760041091ed8-8aaa-4f31-bf3b-b99241ab14cd6002d504966-0a96-4d8c-8e00-c59a6d0a0609600Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud2023-11-13T18:37:55Z2023-11-13T18:37:55Z2023-02-27Bernal C, Ping S, Rojas A, Caballero O, Stittleburg V, de Guillén Y, et al. (2023) Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue. PLoS Negl Trop Dis 17(2): e0010750. https://doi.org/10.1371/journal.pntd.00107501935-2727http://hdl.handle.net/20.500.14066/431810.1371/journal.pntd.00107501935-2735Corresponding author: fati.cardozo@hotmail.com (FC); jjwaggo@emory.edu (JJW)Background. Dengue is the most common vector-borne viral disease worldwide. Most cases are mild, but some evolve into severe dengue (SD), with high lethality. Therefore, it is important to identify biomarkers of severe disease to improve outcomes and judiciously utilize resources. Methods/Principal findings. One hundred forty-five confirmed dengue cases (median age, 42; range <1–91 years), enrolled from February 2018 to March 2020, were selected from an ongoing study of suspected arboviral infections in metropolitan Asunción, Paraguay. Cases included dengue virus types 1, 2, and 4, and severity was categorized according to the 2009 World Health Organization guidelines. Testing for anti-dengue virus IgM and IgG and serum biomarkers (lipopolysaccharide binding protein and chymase) was performed on acute-phase sera in plate-based ELISAs; in addition, a multiplex ELISA platform was used to measure anti-dengue virus and anti-Zika virus IgM and IgG. Complete blood counts and chemistries were performed at the discretion of the care team. Age, gender, and pre-existing comorbidities were associated with SD vs. dengue with/without warning signs in logistic regression with odds ratios (ORs) of 1.07 (per year; 95% confidence interval, 1.03, 1.11), 0.20 (female; 0.05,0.77), and 2.09 (presence; 1.26, 3.48) respectively. In binary logistic regression, for every unit increase in anti-DENV IgG in the multiplex platform, odds of SD increased by 2.54 (1.19–5.42). Platelet count, lymphocyte percent, and elevated chymase were associated with SD in a combined logistic regression model with ORs of 0.99 (1,000/μL; 0.98,0.999), 0.92 (%; 0.86,0.98), and 1.17 (mg/mL; 1.03,1.33) respectively. Conclusions. Multiple, readily available factors were associated with SD in this population. These findings will aid in the early detection of potentially severe dengue cases and inform the development of new prognostics for use in acute-phase and serial samples from dengue cases.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de creación y fortalecimiento de maestrías y doctorados de excelencia18 páginasengPublic Library of ScienceAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess© 2023 Bernal et al.7. SaludAedesArbovirusBiomarcadoresDengueDengue GraveDiagnósticoAedesArbovirusesBiomarkersDengueSevere DengueDiagnosis3.3. 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| spellingShingle | Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue Bernal, Cynthia 7. Salud Aedes Arbovirus Biomarcadores Dengue Dengue Grave Diagnóstico Aedes Arboviruses Biomarkers Dengue Severe Dengue Diagnosis 3.3. Ciencias de la salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| status_str | publishedVersion |
| title | Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue |
| title_full | Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue |
| title_fullStr | Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue |
| title_full_unstemmed | Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue |
| title_short | Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue |
| title_sort | Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue |
| topic | 7. Salud Aedes Arbovirus Biomarcadores Dengue Dengue Grave Diagnóstico Aedes Arboviruses Biomarkers Dengue Severe Dengue Diagnosis 3.3. Ciencias de la salud (salud pública, medicina social, higiene, enfermería, epidemiología) |
| url | http://hdl.handle.net/20.500.14066/4318 |