Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates
Hollow poly(Lactic Acid) (PLA) microcapsules were fabricated using the bubble template method. In this method, microbubbles nucleated inside droplets of a dichloromethane solution of PLA which were located in a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles formed when PLA adsorbe...
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| Format: | article |
| Jezik: | španjolski |
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2019
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| Online pristup: | http://repositorio2.udelas.ac.pa/handle/123456789/362 |
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| _version_ | 1869652468222132224 |
|---|---|
| author | Jay Molino |
| author2 | Svetlana Jojlova Hirofumi Daiguji and Fumio Takemura |
| author2_role | author author author |
| author_browse | Fumio Takemura Hirofumi Daiguji and Jay Molino Svetlana Jojlova |
| author_facet | Jay Molino Svetlana Jojlova Hirofumi Daiguji and Fumio Takemura |
| author_role | author |
| collection | Repositorio Institucional de la Universidad Especializada de las Américas |
| dc.creator.none.fl_str_mv | Jay Molino Svetlana Jojlova Hirofumi Daiguji and Fumio Takemura |
| dc.date.none.fl_str_mv | 2019-01-16 2021-05-18T19:55:39Z 2021-05-18T19:55:39Z |
| dc.format.none.fl_str_mv | application/pdf 213-224 páginas application/pdf |
| dc.identifier.none.fl_str_mv | DOI: 10.3844/ajassp.2019.213.224 http://repositorio2.udelas.ac.pa/handle/123456789/362 |
| dc.language.none.fl_str_mv | spa |
| dc.publisher.none.fl_str_mv | .American Journal of Applied Sciences |
| dc.relation.none.fl_str_mv | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.rights.none.fl_str_mv | https://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-sa/2.0/uk/ |
| dc.source.none.fl_str_mv | reponame:Repositorio Institucional de la Universidad Especializada de las Américas instname:Universidad Especializada de las Américas instacron:UDELAS |
| dc.subject.none.fl_str_mv | Biodegradable Microcapsules Drug Delivery Mass Production of Hollow Capsules Microencapsulation Ultrasound Enhanced Fabrication Ultrasound Contrast Agents |
| dc.title.none.fl_str_mv | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/updatedVersion |
| description | Hollow poly(Lactic Acid) (PLA) microcapsules were fabricated using the bubble template method. In this method, microbubbles nucleated inside droplets of a dichloromethane solution of PLA which were located in a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles formed when PLA adsorbed to the bubble surface by physisorption. Then, the coated microbubbles were spontaneously released from the droplet´s interior into the continuous phase. To increase the production yield of hollow microcapsules in this method, ultrasound was applied to enhance bubble nucleation inside the droplets. Thus to attain uniform hollow PLA microcapsules, the optimum PLA concentration with ultrasound was 30 g L −1 , which is higher than that without ultrasound (2 g L−1 ). At the optimum concentration, the average radius was 0.54 µm, with a polydispersity index of 21.2%. It was found that the equilibrium size of the microbubble template radius was the same with and without ultrasound. The production yield had a tenfold increase when ultrasound was employed. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | lrtest_7d5f77105a3d555f2d40bd6387e9d475 |
| identifier_str_mv | DOI: 10.3844/ajassp.2019.213.224 |
| instacron_str | UDELAS |
| institution | UDELAS |
| instname_str | Universidad Especializada de las Américas |
| language | spa |
| network_acronym_str | lrtest |
| network_name_str | lr |
| oai_identifier_str | oai:repositorio2.udelas.ac.pa:123456789/362 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher.none.fl_str_mv | .American Journal of Applied Sciences |
| reponame_str | Repositorio Institucional de la Universidad Especializada de las Américas |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | https://creativecommons.org/licenses/by-nc-sa/4.0/ https://creativecommons.org/licenses/by-sa/2.0/uk/ |
| spelling | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble TemplatesJay MolinoSvetlana JojlovaHirofumi Daiguji andFumio TakemuraBiodegradable MicrocapsulesDrug DeliveryMass Production of Hollow CapsulesMicroencapsulationUltrasound Enhanced FabricationUltrasound Contrast AgentsHollow poly(Lactic Acid) (PLA) microcapsules were fabricated using the bubble template method. In this method, microbubbles nucleated inside droplets of a dichloromethane solution of PLA which were located in a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles formed when PLA adsorbed to the bubble surface by physisorption. Then, the coated microbubbles were spontaneously released from the droplet´s interior into the continuous phase. To increase the production yield of hollow microcapsules in this method, ultrasound was applied to enhance bubble nucleation inside the droplets. Thus to attain uniform hollow PLA microcapsules, the optimum PLA concentration with ultrasound was 30 g L −1 , which is higher than that without ultrasound (2 g L−1 ). At the optimum concentration, the average radius was 0.54 µm, with a polydispersity index of 21.2%. It was found that the equilibrium size of the microbubble template radius was the same with and without ultrasound. The production yield had a tenfold increase when ultrasound was employed..American Journal of Applied Sciences2021-05-18T19:55:39Z2021-05-18T19:55:39Z2019-01-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/updatedVersionapplication/pdf213-224 páginasapplication/pdfDOI: 10.3844/ajassp.2019.213.224http://repositorio2.udelas.ac.pa/handle/123456789/362spahttps://creativecommons.org/licenses/by-nc-sa/4.0/https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-sa/2.0/uk/reponame:Repositorio Institucional de la Universidad Especializada de las Américasinstname:Universidad Especializada de las Américasinstacron:UDELASoai:repositorio2.udelas.ac.pa:123456789/3622021-05-24T00:00:51Z |
| spellingShingle | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates Jay Molino Biodegradable Microcapsules Drug Delivery Mass Production of Hollow Capsules Microencapsulation Ultrasound Enhanced Fabrication Ultrasound Contrast Agents |
| status_str | updatedVersion |
| title | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates |
| title_full | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates |
| title_fullStr | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates |
| title_full_unstemmed | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates |
| title_short | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates |
| title_sort | Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates |
| topic | Biodegradable Microcapsules Drug Delivery Mass Production of Hollow Capsules Microencapsulation Ultrasound Enhanced Fabrication Ultrasound Contrast Agents |
| url | http://repositorio2.udelas.ac.pa/handle/123456789/362 |