Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama
Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adul...
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| Drugi avtorji: | , , , , , , |
| Format: | article |
| Jezik: | angleščina |
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2018
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| Teme: | |
| Online dostop: | http://repositorio-indicasat.org.pa/handle/123456789/14 |
| Oznake: |
Brez oznak, prvi označite!
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| _version_ | 1869652475980546048 |
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| author | Britton, Gabrielle |
| author2 | O'Bryant, Sid E. Johnson, Leigh A. Hall, James R. Villarreal, Alcibiades E. Oviedo, Diana C. Pérez-Lao, Ambar R. Carreira, María B. |
| author2_role | author author author author author author author |
| author_browse | Britton, Gabrielle Carreira, María B. Hall, James R. Johnson, Leigh A. O'Bryant, Sid E. Oviedo, Diana C. Pérez-Lao, Ambar R. Villarreal, Alcibiades E. |
| author_facet | Britton, Gabrielle O'Bryant, Sid E. Johnson, Leigh A. Hall, James R. Villarreal, Alcibiades E. Oviedo, Diana C. Pérez-Lao, Ambar R. Carreira, María B. |
| author_role | author |
| collection | Repositorio INDICASAT |
| dc.creator.none.fl_str_mv | Britton, Gabrielle O'Bryant, Sid E. Johnson, Leigh A. Hall, James R. Villarreal, Alcibiades E. Oviedo, Diana C. Pérez-Lao, Ambar R. Carreira, María B. |
| dc.date.none.fl_str_mv | 2018-01-01 2020-02-10T14:55:00Z 2020-02-10T14:55:00Z |
| dc.format.none.fl_str_mv | application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | http://repositorio-indicasat.org.pa/handle/123456789/14 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Current Aging Science |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.source.none.fl_str_mv | reponame:Repositorio INDICASAT instname:Instituto de Investigaciones Científicas y Servicios de Alta Tecnología instacron:INDICASAT |
| dc.subject.none.fl_str_mv | Aging disability inflammation depression Hispanics Latin America |
| dc.title.none.fl_str_mv | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults. Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events. Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls. Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | lrtest_d81483fcc401bdcc4733382110f8a0d4 |
| instacron_str | INDICASAT |
| institution | INDICASAT |
| instname_str | Instituto de Investigaciones Científicas y Servicios de Alta Tecnología |
| language | eng |
| network_acronym_str | lrtest |
| network_name_str | lr |
| oai_identifier_str | oai:repositorio-indicasat.org.pa:123456789/14 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher.none.fl_str_mv | Current Aging Science |
| reponame_str | Repositorio INDICASAT |
| repository.mail.fl_str_mv | mail@mail.com |
| repository.name.fl_str_mv |
-
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| repository_id_str | |
| rights_invalid_str_mv | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in PanamaBritton, GabrielleO'Bryant, Sid E.Johnson, Leigh A.Hall, James R.Villarreal, Alcibiades E.Oviedo, Diana C.Pérez-Lao, Ambar R.Carreira, María B.AgingdisabilityinflammationdepressionHispanicsLatin AmericaBackground: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults. Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events. Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls. Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults. Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events. Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls. Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.Current Aging Science2020-02-10T14:55:00Z2020-02-10T14:55:00Z2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://repositorio-indicasat.org.pa/handle/123456789/14enginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/reponame:Repositorio INDICASATinstname:Instituto de Investigaciones Científicas y Servicios de Alta Tecnologíainstacron:INDICASAT2020-05-27T10:06:39Zmail@mail.com - |
| spellingShingle | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama Britton, Gabrielle Aging disability inflammation depression Hispanics Latin America |
| status_str | publishedVersion |
| title | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama |
| title_full | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama |
| title_fullStr | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama |
| title_full_unstemmed | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama |
| title_short | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama |
| title_sort | Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama |
| topic | Aging disability inflammation depression Hispanics Latin America |
| url | http://repositorio-indicasat.org.pa/handle/123456789/14 |