Propiedades conformacionales y energéticas de los intermediarios de replicación de DNA circular

DNA topology changes continuously as replication proceeds. Unwinding of the DNA duplex by helicases is favored by negative supercoiling but it causes the progressive accumulation of positive supercoiling ahead of the replication forks. In covalent closed circular DNA molecules this torsional stress...

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Bibliographic Details

Main Author:	Martínez Chamorro, Víctor Manuel (author)
Format:	doctoralThesis
Language:	Spanish
Published:	2020
Subjects:	1303 I+D en relación con las ciencias médicas ADN circular Biología computacional Método de Montecarlo Replicación del ADN Simulación por computador Termodinámica DNA, circular Computational biology Monte Carlo Method DNA replication Computer simulation Thermodynamics
Online Access:	http://hdl.handle.net/20.500.14066/2931
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