Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy
Somatic mutation analysis and evaluation of microsatellite instability (MSI) have become mandatory for selecting personalized therapy strategies for advanced colorectal cancer and are not available as routine methods in Paraguay. The aims of this study were to analyze the molecular profile as well a...
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| Övriga upphov: | , , , , , , , , , , , , , , , , , , |
| Materialtyp: | article |
| Språk: | engelska |
| Utgiven: |
2019
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| Ämnen: | |
| Länkar: | http://hdl.handle.net/20.500.14066/3656 |
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| _version_ | 1870885384691384320 |
|---|---|
| author | Fleitas, Tania |
| author2 | Martinez Ciarpaglini, Carolina Ayala, Josefina Gauna, Cinthia Denis, Rita Mabel Concepción Yoffe, Ita Sforza, Silvia Martínez de Filártiga Filártiga, María Teresa Pomata, Alicia Ibarrola‐Villava, Maider Arevshatyan, Sipan Burriel, Verónica Boscá, Diego Pastor, Oscar Ferrer, Ana Carrasco, Francisca Mongort, Cristina Navarro, Samuel Ribas, Gloria Cervantes, Andres |
| author2_role | author author author author author author author author author author author author author author author author author author author |
| author_browse | Arevshatyan, Sipan Ayala, Josefina Boscá, Diego Burriel, Verónica Carrasco, Francisca Cervantes, Andres Denis, Rita Mabel Concepción Ferrer, Ana Fleitas, Tania Gauna, Cinthia Ibarrola‐Villava, Maider Martinez Ciarpaglini, Carolina Martínez de Filártiga Filártiga, María Teresa Mongort, Cristina Navarro, Samuel Pastor, Oscar Pomata, Alicia Ribas, Gloria Sforza, Silvia Yoffe, Ita |
| author_facet | Fleitas, Tania Martinez Ciarpaglini, Carolina Ayala, Josefina Gauna, Cinthia Denis, Rita Mabel Concepción Yoffe, Ita Sforza, Silvia Martínez de Filártiga Filártiga, María Teresa Pomata, Alicia Ibarrola‐Villava, Maider Arevshatyan, Sipan Burriel, Verónica Boscá, Diego Pastor, Oscar Ferrer, Ana Carrasco, Francisca Mongort, Cristina Navarro, Samuel Ribas, Gloria Cervantes, Andres |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/3656/1/PINV15-156art.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/3656/2/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/3656/3/PINV15-156art.pdf.txt |
| dc.contributor.other.es.fl_str_mv | Laboratorio Curie S.R.L. (PY) |
| dc.creator.none.fl_str_mv | Fleitas, Tania Martinez Ciarpaglini, Carolina Ayala, Josefina Gauna, Cinthia Denis, Rita Mabel Concepción Yoffe, Ita Sforza, Silvia Martínez de Filártiga Filártiga, María Teresa Pomata, Alicia Ibarrola‐Villava, Maider Arevshatyan, Sipan Burriel, Verónica Boscá, Diego Pastor, Oscar Ferrer, Ana Carrasco, Francisca Mongort, Cristina Navarro, Samuel Ribas, Gloria Cervantes, Andres |
| dc.date.accessioned.none.fl_str_mv | 2022-04-27T00:25:19Z |
| dc.date.available.none.fl_str_mv | 2022-04-27T00:25:19Z |
| dc.date.issued.none.fl_str_mv | 2019 |
| dc.identifier.doi.es.fl_str_mv | 10.1002/cam4.2191 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/3656 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.relation.projectCONACYT.es.fl_str_mv | PINV15-156 |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.copyright.es.fl_str_mv | © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
| dc.subject.classification.es.fl_str_mv | 7. Salud |
| dc.subject.ocde.es.fl_str_mv | CANCER |
| dc.subject.other.es.fl_str_mv | COLORECTAL CANCER MICROSATELLITE INSTABILITY MUTATIONAL PROFILE ONCOCARTA PRECISION MEDICINE |
| dc.title.es.fl_str_mv | Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Somatic mutation analysis and evaluation of microsatellite instability (MSI) have become mandatory for selecting personalized therapy strategies for advanced colorectal cancer and are not available as routine methods in Paraguay. The aims of this study were to analyze the molecular profile as well as the microsatellite status in a series of advanced colorectal patients from two public hospitals from Paraguay, to introduce these methodologies in the routine practice to guide the therapeutic decisions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_490db2180f24165c44477b4a8d0472b2 |
| identifier_str_mv | 10.1002/cam4.2191 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/3656 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
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(PY)2022-04-27T00:25:19Z2022-04-27T00:25:19Z2019http://hdl.handle.net/20.500.14066/365610.1002/cam4.2191Somatic mutation analysis and evaluation of microsatellite instability (MSI) have become mandatory for selecting personalized therapy strategies for advanced colorectal cancer and are not available as routine methods in Paraguay. The aims of this study were to analyze the molecular profile as well as the microsatellite status in a series of advanced colorectal patients from two public hospitals from Paraguay, to introduce these methodologies in the routine practice to guide the therapeutic decisions.Consejo Nacional de Ciencia y TecnologíaPROCIENCIAeng7. SaludCOLORECTAL CANCERMICROSATELLITE INSTABILITYMUTATIONAL PROFILEONCOCARTAPRECISION MEDICINECANCERMolecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionCancer Medicine111PINV15-156info:eu-repo/semantics/openAccess© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.Fleitas, TaniaMartinez Ciarpaglini, CarolinaAyala, JosefinaGauna, CinthiaDenis, Rita Mabel ConcepciónYoffe, ItaSforza, SilviaMartínez de Filártiga Filártiga, María TeresaPomata, AliciaIbarrola‐Villava, MaiderArevshatyan, SipanBurriel, VerónicaBoscá, DiegoPastor, OscarFerrer, AnaCarrasco, FranciscaMongort, CristinaNavarro, SamuelRibas, GloriaCervantes, AndresORIGINALPINV15-156art.pdfPINV15-156art.pdfapplication/pdf860389http://repositorio.conacyt.gov.py/bitstream/20.500.14066/3656/1/PINV15-156art.pdf7a143ab394455e0c15fa518ed5f3da0eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/3656/2/license.txt858b22fda432bd774e469302988c1974MD52TEXTPINV15-156art.pdf.txtPINV15-156art.pdf.txtExtracted texttext/plain44113http://repositorio.conacyt.gov.py/bitstream/20.500.14066/3656/3/PINV15-156art.pdf.txt15ede44408c3912c227b27f36614bab7MD5320.500.14066/3656oai:repositorio.conacyt.gov.py:20.500.14066/36562026-02-12 19:30:29.751Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.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 |
| spellingShingle | Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy Fleitas, Tania 7. Salud COLORECTAL CANCER MICROSATELLITE INSTABILITY MUTATIONAL PROFILE ONCOCARTA PRECISION MEDICINE CANCER |
| status_str | publishedVersion |
| title | Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy |
| title_full | Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy |
| title_fullStr | Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy |
| title_full_unstemmed | Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy |
| title_short | Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy |
| title_sort | Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy |
| topic | 7. Salud COLORECTAL CANCER MICROSATELLITE INSTABILITY MUTATIONAL PROFILE ONCOCARTA PRECISION MEDICINE CANCER |
| url | http://hdl.handle.net/20.500.14066/3656 |