Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting
Address for correspondence: Dr. Mirta Noemi Mesquita Ramirez, Department of Teaching and Research, General Pediatric Hospital Children of Acosta Ñu, Avenida Bacigalupo y de La Victoria, Reducto, San Lorenzo 111 475, Paraguay. E‑mail: mirtanmr@gmail.com
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| Other Authors: | , , , |
| Format: | article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://doi.org/10.4103/jcn.jcn_33_23 http://hdl.handle.net/20.500.14066/4507 |
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| _version_ | 1870612070622298112 |
|---|---|
| author | Mesquita Ramírez, Mirta |
| author2 | Samudio Acevedo, Margarita Cardozo Sarubbi, Olivia Carolina Carrera Vargas, Dina Carmen Villalba Cabral, Pedro Luis |
| author2_role | author author author author |
| author_browse | Cardozo Sarubbi, Olivia Carolina Carrera Vargas, Dina Carmen Mesquita Ramírez, Mirta Samudio Acevedo, Margarita Villalba Cabral, Pedro Luis |
| author_facet | Mesquita Ramírez, Mirta Samudio Acevedo, Margarita Cardozo Sarubbi, Olivia Carolina Carrera Vargas, Dina Carmen Villalba Cabral, Pedro Luis |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/1/Intravenous%20sildenafil%20for%20the%20treatment%20of%20persistent%20pulmonary%20hypertension%20of%20the%20newborn%20in%20a%20resource-limited%20setting.pdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/2/license_rdf http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/3/license.txt http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/4/Intravenous%20sildenafil%20for%20the%20treatment%20of%20persistent%20pulmonary%20hypertension.jpg http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/5/Intravenous%20sildenafil%20for%20the%20treatment%20of%20persistent%20pulmonary%20hypertension%20of%20the%20newborn%20in%20a%20resource-limited%20setting.pdf.txt |
| dc.contributor.other.es.fl_str_mv | Universidad Católica Nuestra Señora de la Asunción |
| dc.creator.none.fl_str_mv | Mesquita Ramírez, Mirta Samudio Acevedo, Margarita Cardozo Sarubbi, Olivia Carolina Carrera Vargas, Dina Carmen Villalba Cabral, Pedro Luis |
| dc.date.accessioned.none.fl_str_mv | 2025-01-20T15:10:01Z |
| dc.date.available.none.fl_str_mv | 2025-01-20T15:10:01Z |
| dc.date.issued.none.fl_str_mv | 2023-07-12 |
| dc.identifier.citation.en.fl_str_mv | Mesquita Ramírez, M. N., Samudio Acevedo, M., Cardozo Sarubbi, O. C., Carrera, D. C., & Villalba Cabral, P. L. (2023). Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource limited setting. Journal of Clinical Neonatology, 12(3), 99-104. https://doi.org/10.4103/jcn.jcn_33_23 |
| dc.identifier.doi.es.fl_str_mv | 10.4103/jcn.jcn_33_23 |
| dc.identifier.essn.es.fl_str_mv | 1658-6093 |
| dc.identifier.issn.es.fl_str_mv | 2249-4847 |
| dc.identifier.other.es.fl_str_mv | https://doi.org/10.4103/jcn.jcn_33_23 |
| dc.identifier.uri.none.fl_str_mv | http://hdl.handle.net/20.500.14066/4507 |
| dc.language.iso.es.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Wolters Kluwer - Medknow Publications |
| dc.relation.projectCONACYT.es.fl_str_mv | PINV15-1022 |
| dc.rights.*.fl_str_mv | Atribución-NoComercial-CompartirIgual 4.0 Internacional |
| dc.rights.accessRights.es.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.copyright.es.fl_str_mv | © 2023 Journal of Clinical Neonatology |
| dc.rights.uri.*.fl_str_mv | http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.subject.classification.es.fl_str_mv | 7. Salud 7.4. Seguimiento sanitario |
| dc.subject.mesh.en.fl_str_mv | Sildenafil citrate Infant Nitrous oxide Newborn Persistent fetal circulation syndrome Vasodilator agents |
| dc.subject.mesh.es.fl_str_mv | Citrato de sildenafil Lactante Óxido nitroso Recién nacido Síndrome de circulación fetal persistente Vasodilatadores |
| dc.subject.ocde.es.fl_str_mv | 3. Ciencias Médicas y de la Salud 3.1. Medicina Básica (anatomía, citología, fisiología, genética, farmacia, farmacología, toxicología, inmunología e inmunohematología, química clínica, microbiología clínica, patología) |
| dc.subject.other.es.fl_str_mv | Oxygenation index Persistent pulmonary hypertension of the newborn Sildenafil |
| dc.title.es.fl_str_mv | Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting |
| dc.type.es.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Address for correspondence: Dr. Mirta Noemi Mesquita Ramirez, Department of Teaching and Research, General Pediatric Hospital Children of Acosta Ñu, Avenida Bacigalupo y de La Victoria, Reducto, San Lorenzo 111 475, Paraguay. E‑mail: mirtanmr@gmail.com |
| eu_rights_str_mv | openAccess |
| format | article |
| id | CONACYT_a586dc1c6d4ec41741fa1dae3fa135cc |
| identifier_str_mv | Mesquita Ramírez, M. N., Samudio Acevedo, M., Cardozo Sarubbi, O. C., Carrera, D. C., & Villalba Cabral, P. L. (2023). Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource limited setting. Journal of Clinical Neonatology, 12(3), 99-104. https://doi.org/10.4103/jcn.jcn_33_23 2249-4847 10.4103/jcn.jcn_33_23 1658-6093 |
| language | eng |
| network_acronym_str | CONACYT |
| network_name_str | Repositorio Institucional CONACYT |
| oai_identifier_str | oai:repositorio.conacyt.gov.py:20.500.14066/4507 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| repository.mail.fl_str_mv | repositorio.institucional@conacyt.gov.py |
| repository.name.fl_str_mv | Repositorio Institucional CONACYT |
| repository_id_str | |
| rights_invalid_str_mv | Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ © 2023 Journal of Clinical Neonatology |
| spelling | f4cf5d89-b3ec-4271-b479-c3a809ae3c8960010346005abb1249-16c3-4e0c-9471-64fefd10d00a600a5792a5e-f1b8-4d28-88db-db7abf63b3f76001182600Universidad Católica Nuestra Señora de la Asunción2025-01-20T15:10:01Z2025-01-20T15:10:01Z2023-07-12Mesquita Ramírez, M. N., Samudio Acevedo, M., Cardozo Sarubbi, O. C., Carrera, D. C., & Villalba Cabral, P. L. (2023). Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource limited setting. Journal of Clinical Neonatology, 12(3), 99-104. https://doi.org/10.4103/jcn.jcn_33_232249-4847https://doi.org/10.4103/jcn.jcn_33_23http://hdl.handle.net/20.500.14066/450710.4103/jcn.jcn_33_231658-6093Address for correspondence: Dr. Mirta Noemi Mesquita Ramirez, Department of Teaching and Research, General Pediatric Hospital Children of Acosta Ñu, Avenida Bacigalupo y de La Victoria, Reducto, San Lorenzo 111 475, Paraguay. E‑mail: mirtanmr@gmail.comIntroduction: Treatment of severe persistent pulmonary hypertension of the newborn (PPHN) is based on the administration of selective pulmonary vasodilators. Inhaled nitric oxide is the only vasodilator therapy approved by the Food and Drug Administration. Non-selective vasodilator such as sildenafil has been the treatment available administered orally in most developing countries to manage newborn with PPHN. The aim of the study was to describe the effects and tolerability of intravenous (IV) sildenafil, as a loading dose of 0.4 mg/kg, followed by a continuous infusion of 1.6 mg/kg for 72 h on the oxygenation index (OI) in neonates with PPHN. Materials and Methods: This was an exploratory observational prospective study. Newborns ≥35 weeks of gestational age, post-natal age ≤72 h, with PPHN and an OI ≥20 were included in the study. Sildenafil was administered intravenously as a loading dose of 0.4 mg/kg, followed by a continuous infusion of 1.6 mg/kg for 72 h. During the sildenafil infusion, monitoring of vital signs and respiratory parameters was performed. The data were analysed with the SPSS v21. Results: Twenty-five infants were included. A significant improvement (P = 0.01) of OI (at admission, median: 25 and interquartile range [IQR] = 8) was observed at the end of the loading dose (3 h) (18 IQR = 4) and at 72 h (7 IQR = 4). No serious adverse effects were observed. Before hospital discharge, seven patients died. Conclusions: IV sildenafil administered, in newborns with PPHN with an IO ≥20, improved oxygenation in most of the patients without serious side effects.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloengWolters Kluwer - Medknow PublicationsAtribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccess© 2023 Journal of Clinical Neonatology7. Salud7.4. Seguimiento sanitarioSildenafil citrateInfantNitrous oxideNewbornPersistent fetal circulation syndromeVasodilator agentsCitrato de sildenafilLactanteÓxido nitrosoRecién nacidoSíndrome de circulación fetal persistenteVasodilatadoresOxygenation indexPersistent pulmonary hypertension of the newbornSildenafil3. Ciencias Médicas y de la Salud3.1. Medicina Básica (anatomía, citología, fisiología, genética, farmacia, farmacología, toxicología, inmunología e inmunohematología, química clínica, microbiología clínica, patología)Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited settinginfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion3Journal of Clinical Neonatology99104PINV15-102212Mesquita Ramírez, MirtaSamudio Acevedo, MargaritaCardozo Sarubbi, Olivia CarolinaCarrera Vargas, Dina CarmenVillalba Cabral, Pedro LuisORIGINALIntravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting.pdfIntravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting.pdfArtículo científicoapplication/pdf778414http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/1/Intravenous%20sildenafil%20for%20the%20treatment%20of%20persistent%20pulmonary%20hypertension%20of%20the%20newborn%20in%20a%20resource-limited%20setting.pdf84e9b967554665dc6910ed1864963d9dMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81031http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/2/license_rdf934f4ca17e109e0a05eaeaba504d7ce4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81698http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/3/license.txt858b22fda432bd774e469302988c1974MD53THUMBNAILIntravenous sildenafil for the treatment of persistent pulmonary hypertension.jpgIntravenous sildenafil for the treatment of persistent pulmonary hypertension.jpgVista de primera página de artículo científicoimage/jpeg1208957http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/4/Intravenous%20sildenafil%20for%20the%20treatment%20of%20persistent%20pulmonary%20hypertension.jpg29e78d750f7cac41ad08ca8e802e936cMD54TEXTIntravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting.pdf.txtIntravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting.pdf.txtExtracted texttext/plain33291http://repositorio.conacyt.gov.py/bitstream/20.500.14066/4507/5/Intravenous%20sildenafil%20for%20the%20treatment%20of%20persistent%20pulmonary%20hypertension%20of%20the%20newborn%20in%20a%20resource-limited%20setting.pdf.txt5bd9a89a42f6eb6bdb76601e607e8682MD5520.500.14066/4507oai:repositorio.conacyt.gov.py:20.500.14066/45072026-02-12 19:30:39.124Repositorio Institucional CONACYTrepositorio.institucional@conacyt.gov.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 |
| spellingShingle | Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting Mesquita Ramírez, Mirta 7. Salud 7.4. Seguimiento sanitario Sildenafil citrate Infant Nitrous oxide Newborn Persistent fetal circulation syndrome Vasodilator agents Citrato de sildenafil Lactante Óxido nitroso Recién nacido Síndrome de circulación fetal persistente Vasodilatadores Oxygenation index Persistent pulmonary hypertension of the newborn Sildenafil 3. Ciencias Médicas y de la Salud 3.1. Medicina Básica (anatomía, citología, fisiología, genética, farmacia, farmacología, toxicología, inmunología e inmunohematología, química clínica, microbiología clínica, patología) |
| status_str | publishedVersion |
| title | Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting |
| title_full | Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting |
| title_fullStr | Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting |
| title_full_unstemmed | Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting |
| title_short | Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting |
| title_sort | Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting |
| topic | 7. Salud 7.4. Seguimiento sanitario Sildenafil citrate Infant Nitrous oxide Newborn Persistent fetal circulation syndrome Vasodilator agents Citrato de sildenafil Lactante Óxido nitroso Recién nacido Síndrome de circulación fetal persistente Vasodilatadores Oxygenation index Persistent pulmonary hypertension of the newborn Sildenafil 3. Ciencias Médicas y de la Salud 3.1. Medicina Básica (anatomía, citología, fisiología, genética, farmacia, farmacología, toxicología, inmunología e inmunohematología, química clínica, microbiología clínica, patología) |
| url | https://doi.org/10.4103/jcn.jcn_33_23 http://hdl.handle.net/20.500.14066/4507 |