Buchumschlag

Two-dimensional gel electrophoresis to study the activity of type iia topoisomerases on plasmid replication intermediates

DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined. However, their ability to relax supercoiling and unlink the pre-c...

Ausführliche Beschreibung

Gespeichert in:
1. Verfasser: Cebrian, Jorge (author)
Weitere Verfasser: Martínez, Víctor (author), Hernández, Pablo (author), Krimer, Dora (author), Fernández Nestosa, María José (author), Schvartzman, Jorge Bernardo (author)
Format: article
Sprache:Englisch
Veröffentlicht: 2021
Schlagworte:
1303 I+D en relación con las Ciencias médicas
DNA TOPOLOGY
REPLICATION
SUPERCOILING
PRE-CATENATION
TWO-DIMENSIONAL AGAROSE GEL ELECTROPHORESIS
SISTEMAS DE INFORMACION
Online-Zugang:http://hdl.handle.net/20.500.14066/3839
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Zusammenfassung:DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined. However, their ability to relax supercoiling and unlink the pre-catenanes of partially replicated molecules has received little attention.

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